Chromosomal assignment of the human homologue encoding SGP-2

Kevin Slawin; Ihor S. Sawczuk; Carl A. Olsson; Ralph Buttyan

doi:10.1016/S0006-291X(05)80187-1

Chromosomal assignment of the human homologue encoding SGP-2

Kevin Slawin, Ihor S. Sawczuk, Carl A. Olsson, Ralph Buttyan

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Although originally characterized as a constituitively expressed gene product in mammalian Sertoli cells, sulfated glycoprotein-2 (SGP-2) has gained widespread attention due to its remarkably rapid and sizable induction in numerous types of mammalian cells undergoing apoptosis, or programmed death. In order to identify the chromosomal assignment for the human homologue of SGP-2, we performed Southern blot analysis of Bgl II restricted genomic DNA extracted from a panel of cloned hamster-human hybrid cell lines and screened for the presence of restriction fragments homologous to SGP-2. The results of this analysis indicate that the human homologue of SGP-2 resides on chromosome 8.

Original language	English
Pages (from-to)	160-164
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	172
Issue number	1
DOIs	https://doi.org/10.1016/S0006-291X(05)80187-1
State	Published - 15 Oct 1990
Externally published	Yes

Access to Document

10.1016/S0006-291X(05)80187-1

Cite this

@article{c7f6064de726468094cffc5472a69e5e,

title = "Chromosomal assignment of the human homologue encoding SGP-2",

abstract = "Although originally characterized as a constituitively expressed gene product in mammalian Sertoli cells, sulfated glycoprotein-2 (SGP-2) has gained widespread attention due to its remarkably rapid and sizable induction in numerous types of mammalian cells undergoing apoptosis, or programmed death. In order to identify the chromosomal assignment for the human homologue of SGP-2, we performed Southern blot analysis of Bgl II restricted genomic DNA extracted from a panel of cloned hamster-human hybrid cell lines and screened for the presence of restriction fragments homologous to SGP-2. The results of this analysis indicate that the human homologue of SGP-2 resides on chromosome 8.",

author = "Kevin Slawin and Sawczuk, \{Ihor S.\} and Olsson, \{Carl A.\} and Ralph Buttyan",

note = "Funding Information: This work was supported, in part, by U.S. Public Health Service Grants from the N.I.D.D.K (DK 40832 to I.S.S.) and from the N.C.I. (CA 47848 to R.B.).",

year = "1990",

month = oct,

day = "15",

doi = "10.1016/S0006-291X(05)80187-1",

language = "English",

volume = "172",

pages = "160--164",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Chromosomal assignment of the human homologue encoding SGP-2

AU - Slawin, Kevin

AU - Sawczuk, Ihor S.

AU - Olsson, Carl A.

AU - Buttyan, Ralph

N1 - Funding Information: This work was supported, in part, by U.S. Public Health Service Grants from the N.I.D.D.K (DK 40832 to I.S.S.) and from the N.C.I. (CA 47848 to R.B.).

PY - 1990/10/15

Y1 - 1990/10/15

N2 - Although originally characterized as a constituitively expressed gene product in mammalian Sertoli cells, sulfated glycoprotein-2 (SGP-2) has gained widespread attention due to its remarkably rapid and sizable induction in numerous types of mammalian cells undergoing apoptosis, or programmed death. In order to identify the chromosomal assignment for the human homologue of SGP-2, we performed Southern blot analysis of Bgl II restricted genomic DNA extracted from a panel of cloned hamster-human hybrid cell lines and screened for the presence of restriction fragments homologous to SGP-2. The results of this analysis indicate that the human homologue of SGP-2 resides on chromosome 8.

AB - Although originally characterized as a constituitively expressed gene product in mammalian Sertoli cells, sulfated glycoprotein-2 (SGP-2) has gained widespread attention due to its remarkably rapid and sizable induction in numerous types of mammalian cells undergoing apoptosis, or programmed death. In order to identify the chromosomal assignment for the human homologue of SGP-2, we performed Southern blot analysis of Bgl II restricted genomic DNA extracted from a panel of cloned hamster-human hybrid cell lines and screened for the presence of restriction fragments homologous to SGP-2. The results of this analysis indicate that the human homologue of SGP-2 resides on chromosome 8.

UR - https://www.scopus.com/pages/publications/0025155657

U2 - 10.1016/S0006-291X(05)80187-1

DO - 10.1016/S0006-291X(05)80187-1

M3 - Article

C2 - 2222466

AN - SCOPUS:0025155657

SN - 0006-291X

VL - 172

SP - 160

EP - 164

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 1

ER -

Chromosomal assignment of the human homologue encoding SGP-2

Abstract

Access to Document

Fingerprint

Cite this