Chromatin accessibility provides a window into the genetic etiology of human brain disease

Keyphrases

• Human Brain 100%
• Brain Diseases 100%
• Genetic Etiology 100%
• Chromatin Accessibility 100%
• Clinical Application 33%
• Gene Expression 33%
• Neurodegenerative Diseases 33%
• Chromatin 33%
• Genome-wide Association Study 33%
• Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) 33%
• Chromatin Structure 33%
• Risk Variant 33%
• Genetic Components 33%
• Chromatin Dynamics 33%
• Functional Validation 33%
• Profiling Method 33%
• Gene Regulatory Programs 33%
• Computational Tools 33%
• Non-coding Genome 33%
• High-quality Data 33%
• Transcriptomic Data 33%
• High-throughput Sequencing 33%
• Neuropsychiatric Diseases 33%
• Phenotypic Drug Discovery 33%
• Cis-regulatory Elements 33%
• Assay for Transposase-Accessible Chromatin 33%
• Targeted Gene 33%
• Element Structure 33%
• Disease-associated SNPs 33%
• Single-cell Technologies 33%

Neuroscience

• Brain Disease 100%
• Gene Expression 50%
• Neurodegenerative Disorder 50%
• Genome-Wide Association Study 50%
• Chromatin Structure 50%
• Regulator Gene 50%
• CRISPR 50%
• Transcriptomics 50%
• Transposase 50%
• Regulatory Sequence 50%

Biochemistry, Genetics and Molecular Biology

• Chromatin Accessibility 100%