Choroidal blood flow in diabetic retinopathy

Maurice E. Langham, Rhonda Grebe, Sharon Hopkins, Sergiu Marcus, Michael Sebag

Research output: Contribution to journalArticlepeer-review

117 Scopus citations

Abstract

The ocular hemodynamics in diabetic patients with increasingly severe retinopathy have been evaluated using a non-invasive computerized methodology. In a group of 19 healthy volunteers the mean ophthalmic arterial pressure and the ocular pulsatile blood flow were 83 ± 2·4 mmHg and 648 ± 42 μl min-1 respectively. Nine diabetics with no apparent retinopathy had ophthalmic pressures and pulsatile blood flows similar to those in the control subjects. In 11 diabetic patients with background retinopathy the mean pulsatile blood flow was 471 ± 70 μl min-1. Thirteen diabetics with proliferative retinopathy had a pulsatile blood flow of 210 ± 37 μl min-1 and abnormally low ophthalmic arterial pressures. The results provide evidence that the choroidal blood flow decreases with the severity of the retinopathy in diabetes due to increased vascular resistance and a decreased ocular perfusion pressure.

Original languageEnglish
Pages (from-to)167-173
Number of pages7
JournalExperimental Eye Research
Volume52
Issue number2
DOIs
StatePublished - Feb 1991
Externally publishedYes

Keywords

  • angiotensin
  • choroidal blood flow
  • diabetes
  • intraocular pressure pulse
  • ophthalmic arterial pressure
  • retinopathy

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