TY - JOUR
T1 - Choosing the Right Therapy at the Right Time for Pediatric Inflammatory Bowel Disease
T2 - Does Sequence Matter
AU - Spencer, Elizabeth A.
N1 - Publisher Copyright:
Copyright © 2023 Elsevier Inc. All rights reserved.
PY - 2023/9
Y1 - 2023/9
N2 - Despite the enlarging therapeutic armamentarium, IBD is still plagued by a therapeutic ceiling. Precision medicine, with the selection of the "rights," may present a solution, and this review will discuss the critical process of pairing the right patient with right therapy at the right time. Firstly, the review will discuss the shift to and evidence behind early effective therapy. Then, it delves into promising future strategies of patient profiling to identify a patients' biological pathway(s) and prognosis. Finally, the review lays out practical considerations that drive treatment selection, particularly the impact of the therapeutic sequence.
AB - Despite the enlarging therapeutic armamentarium, IBD is still plagued by a therapeutic ceiling. Precision medicine, with the selection of the "rights," may present a solution, and this review will discuss the critical process of pairing the right patient with right therapy at the right time. Firstly, the review will discuss the shift to and evidence behind early effective therapy. Then, it delves into promising future strategies of patient profiling to identify a patients' biological pathway(s) and prognosis. Finally, the review lays out practical considerations that drive treatment selection, particularly the impact of the therapeutic sequence.
KW - Biologic therapies
KW - Crohn's disease
KW - Early effective therapy
KW - IBD
KW - Pediatric
KW - Precision medicine
KW - Ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=85166599398&partnerID=8YFLogxK
U2 - 10.1016/j.gtc.2023.05.006
DO - 10.1016/j.gtc.2023.05.006
M3 - Review article
C2 - 37543397
AN - SCOPUS:85166599398
SN - 0889-8553
VL - 52
SP - 517
EP - 534
JO - Gastroenterology Clinics of North America
JF - Gastroenterology Clinics of North America
IS - 3
ER -