Chondromodulin I is a bone remodeling factor

Yuko Nakamichi; Chisa Shukunami; Takashi Yamada; Ken ichi Aihara; Hirotaka Kawano; Takashi Sato; Yuriko Nishizaki; Yoko Yamamoto; Masayo Shindo; Kimihiro Yoshimura; Takashi Nakamura; Naoyuki Takahashi; Hiroshi Kawaguchi; Yuji Hiraki; Shigeaki Kato

doi:10.1128/MCB.23.2.636-644.2003

Chondromodulin I is a bone remodeling factor

Yuko Nakamichi, Chisa Shukunami, Takashi Yamada, Ken ichi Aihara, Hirotaka Kawano, Takashi Sato, Yuriko Nishizaki, Yoko Yamamoto, Masayo Shindo, Kimihiro Yoshimura, Takashi Nakamura, Naoyuki Takahashi, Hiroshi Kawaguchi, Yuji Hiraki, Shigeaki Kato

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Chondromodulin I (ChM-I) was supposed from its limited expression in cartilage and its functions in cultured chondrocytes as a major regulator in cartilage development. Here, we generated mice deficient in ChM-I by targeted disruption of the ChM-I gene. No overt abnormality was detected in endochondral bone formation during embryogenesis and cartilage development during growth stages of ChM-I^-/- mice. However, a significant increase in bone mineral density with lowered bone resorption with respect to formation was unexpectedly found in adult ChM-I^-/- mice. Thus, the present study established that ChM-I is a bone remodeling factor.

Original language	English
Pages (from-to)	636-644
Number of pages	9
Journal	Molecular and Cellular Biology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1128/MCB.23.2.636-644.2003
State	Published - Jan 2003
Externally published	Yes

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10.1128/MCB.23.2.636-644.2003

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title = "Chondromodulin I is a bone remodeling factor",

abstract = "Chondromodulin I (ChM-I) was supposed from its limited expression in cartilage and its functions in cultured chondrocytes as a major regulator in cartilage development. Here, we generated mice deficient in ChM-I by targeted disruption of the ChM-I gene. No overt abnormality was detected in endochondral bone formation during embryogenesis and cartilage development during growth stages of ChM-I-/- mice. However, a significant increase in bone mineral density with lowered bone resorption with respect to formation was unexpectedly found in adult ChM-I-/- mice. Thus, the present study established that ChM-I is a bone remodeling factor.",

author = "Yuko Nakamichi and Chisa Shukunami and Takashi Yamada and Aihara, {Ken ichi} and Hirotaka Kawano and Takashi Sato and Yuriko Nishizaki and Yoko Yamamoto and Masayo Shindo and Kimihiro Yoshimura and Takashi Nakamura and Naoyuki Takahashi and Hiroshi Kawaguchi and Yuji Hiraki and Shigeaki Kato",

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T1 - Chondromodulin I is a bone remodeling factor

AU - Nakamichi, Yuko

AU - Shukunami, Chisa

AU - Yamada, Takashi

AU - Aihara, Ken ichi

AU - Kawano, Hirotaka

AU - Sato, Takashi

AU - Nishizaki, Yuriko

AU - Yamamoto, Yoko

AU - Shindo, Masayo

AU - Yoshimura, Kimihiro

AU - Nakamura, Takashi

AU - Takahashi, Naoyuki

AU - Kawaguchi, Hiroshi

AU - Hiraki, Yuji

AU - Kato, Shigeaki

PY - 2003/1

Y1 - 2003/1

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AB - Chondromodulin I (ChM-I) was supposed from its limited expression in cartilage and its functions in cultured chondrocytes as a major regulator in cartilage development. Here, we generated mice deficient in ChM-I by targeted disruption of the ChM-I gene. No overt abnormality was detected in endochondral bone formation during embryogenesis and cartilage development during growth stages of ChM-I-/- mice. However, a significant increase in bone mineral density with lowered bone resorption with respect to formation was unexpectedly found in adult ChM-I-/- mice. Thus, the present study established that ChM-I is a bone remodeling factor.

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Chondromodulin I is a bone remodeling factor

Abstract

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