TY - JOUR
T1 - Chondroid tenosynovial giant cell tumor
T2 - A clinicopathological and immunohistochemical analysis of 5 new cases
AU - Hoch, Benjamin L.
AU - Garcia, Roberto A.
AU - Smalberger, Gert J.
PY - 2011/4
Y1 - 2011/4
N2 - Tenosynovial giant cell tumor (TGCT) arises from the synovium of joints or tendon sheaths. Chondroid metaplasia in TGCT is rare with only 4 well-documented cases reported in the literature. The authors describe the morphological features and immunophenotype of 5 new cases of chondroid TGCT emphasizing a broader range of matrix patterns in these tumors and an expanded immunophenotype, specifically, staining for clusterin and podoplanin which have recently been found to be expressed in conventional TGCTs. Chondroid metaplasia was extensive in 3 cases. Matrix patterns included chondromyxoid, chondro-osseous, hyaline-like, and lace-like calcification similar to that seen in chondroblastoma. The authors conclude that chondroid TGCT is a rare, distinct synovial tumor with a predilection for the temporomandibular joint that has a similar immunophenotype as conventional TGCT. Chondroid metaplasia may be extensive and have a variety of matrix patterns. Chondroid TGCT needs to be distinguished from other chondroid lesions, including chondroblastoma and chondrosarcoma.
AB - Tenosynovial giant cell tumor (TGCT) arises from the synovium of joints or tendon sheaths. Chondroid metaplasia in TGCT is rare with only 4 well-documented cases reported in the literature. The authors describe the morphological features and immunophenotype of 5 new cases of chondroid TGCT emphasizing a broader range of matrix patterns in these tumors and an expanded immunophenotype, specifically, staining for clusterin and podoplanin which have recently been found to be expressed in conventional TGCTs. Chondroid metaplasia was extensive in 3 cases. Matrix patterns included chondromyxoid, chondro-osseous, hyaline-like, and lace-like calcification similar to that seen in chondroblastoma. The authors conclude that chondroid TGCT is a rare, distinct synovial tumor with a predilection for the temporomandibular joint that has a similar immunophenotype as conventional TGCT. Chondroid metaplasia may be extensive and have a variety of matrix patterns. Chondroid TGCT needs to be distinguished from other chondroid lesions, including chondroblastoma and chondrosarcoma.
KW - chondroid
KW - pigmented villonodular synovitis
KW - tenosynovial giant cell tumor
UR - http://www.scopus.com/inward/record.url?scp=79953858739&partnerID=8YFLogxK
U2 - 10.1177/1066896910381899
DO - 10.1177/1066896910381899
M3 - Article
C2 - 21087985
AN - SCOPUS:79953858739
SN - 1066-8969
VL - 19
SP - 180
EP - 187
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
IS - 2
ER -