Cholinergic underactivity in human memory disorders

Kenneth L. Davis; Henry I. Yamamura

doi:10.1016/0024-3205(78)90100-5

Cholinergic underactivity in human memory disorders

Kenneth L. Davis, Henry I. Yamamura

Research output: Contribution to journal › Short survey › peer-review

82 Scopus citations

Abstract

An age related decrease in central cholinergic neurons that is particularly severe in patients with senile dementia may underlie the cognitive impairment of the aged. This possibility is supported by pharmacological studies demonstrating a decrement in memory processes following administration of anticholinergic drugs and an improvement in some aspects of memory function following the administration of cholinomimetics. The ability of drugs that increase cholinergic activity to improve cognitive processes in the elderly and patients with senile dementia will probably depend on the degree of cholinergic receptor degeneration in these patients.

Original language	English
Pages (from-to)	1729-1733
Number of pages	5
Journal	Life Sciences
Volume	23
Issue number	17-18
DOIs	https://doi.org/10.1016/0024-3205(78)90100-5
State	Published - 30 Oct 1978
Externally published	Yes

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title = "Cholinergic underactivity in human memory disorders",

abstract = "An age related decrease in central cholinergic neurons that is particularly severe in patients with senile dementia may underlie the cognitive impairment of the aged. This possibility is supported by pharmacological studies demonstrating a decrement in memory processes following administration of anticholinergic drugs and an improvement in some aspects of memory function following the administration of cholinomimetics. The ability of drugs that increase cholinergic activity to improve cognitive processes in the elderly and patients with senile dementia will probably depend on the degree of cholinergic receptor degeneration in these patients.",

author = "Davis, {Kenneth L.} and Yamamura, {Henry I.}",

note = "Funding Information: This research was supported in part by the Medical Research Service of the Veterans Administration, USPHS Specialized Research Center Grant (MH-30854), and by a USPHS Grant (MH-30626) . H .I .Yamamura is a recipient of a RS DA (MH-00095) .",

year = "1978",

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doi = "10.1016/0024-3205(78)90100-5",

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T1 - Cholinergic underactivity in human memory disorders

AU - Davis, Kenneth L.

AU - Yamamura, Henry I.

N1 - Funding Information: This research was supported in part by the Medical Research Service of the Veterans Administration, USPHS Specialized Research Center Grant (MH-30854), and by a USPHS Grant (MH-30626) . H .I .Yamamura is a recipient of a RS DA (MH-00095) .

PY - 1978/10/30

Y1 - 1978/10/30

N2 - An age related decrease in central cholinergic neurons that is particularly severe in patients with senile dementia may underlie the cognitive impairment of the aged. This possibility is supported by pharmacological studies demonstrating a decrement in memory processes following administration of anticholinergic drugs and an improvement in some aspects of memory function following the administration of cholinomimetics. The ability of drugs that increase cholinergic activity to improve cognitive processes in the elderly and patients with senile dementia will probably depend on the degree of cholinergic receptor degeneration in these patients.

AB - An age related decrease in central cholinergic neurons that is particularly severe in patients with senile dementia may underlie the cognitive impairment of the aged. This possibility is supported by pharmacological studies demonstrating a decrement in memory processes following administration of anticholinergic drugs and an improvement in some aspects of memory function following the administration of cholinomimetics. The ability of drugs that increase cholinergic activity to improve cognitive processes in the elderly and patients with senile dementia will probably depend on the degree of cholinergic receptor degeneration in these patients.

UR - http://www.scopus.com/inward/record.url?scp=0018179005&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(78)90100-5

DO - 10.1016/0024-3205(78)90100-5

M3 - Short survey

C2 - 364228

AN - SCOPUS:0018179005

SN - 0024-3205

VL - 23

SP - 1729

EP - 1733

JO - Life Sciences

JF - Life Sciences

IS - 17-18

ER -

Cholinergic underactivity in human memory disorders

Abstract

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