Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus

Robert D. Blitzer; Orlando Gil; Emmanuel M. Landau

doi:10.1016/0304-3940(90)90835-W

Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus

Robert D. Blitzer
, Orlando Gil
, Emmanuel M. Landau

Research output: Contribution to journal › Article › peer-review

178 Scopus citations

Abstract

The effect of the cholinergic agonist carbachol on a putative substrate for memory (long-term potentiation; LTP) was investigated in slices of rat hippocampus (CA1 region). Carbachol (5 μM) increased LTP when the presynaptic depression of the EPSP was controlled. The results indicate that carbachol enhances the effectiveness of the tetanus, probably through postsynaptic mechanisms. This effect may have implications for the role of acetylcholine in memory and the use of cholinergics in memory disorders.

Original language	English
Pages (from-to)	207-210
Number of pages	4
Journal	Neuroscience Letters
Volume	119
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(90)90835-W
State	Published - 13 Nov 1990

Keywords

Acetylcholine
Carbachol
Hippocampus
Long-term potentiation
Rat
Synaptic plasticity

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title = "Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus",

abstract = "The effect of the cholinergic agonist carbachol on a putative substrate for memory (long-term potentiation; LTP) was investigated in slices of rat hippocampus (CA1 region). Carbachol (5 μM) increased LTP when the presynaptic depression of the EPSP was controlled. The results indicate that carbachol enhances the effectiveness of the tetanus, probably through postsynaptic mechanisms. This effect may have implications for the role of acetylcholine in memory and the use of cholinergics in memory disorders.",

keywords = "Acetylcholine, Carbachol, Hippocampus, Long-term potentiation, Rat, Synaptic plasticity",

author = "Blitzer, \{Robert D.\} and Orlando Gil and Landau, \{Emmanuel M.\}",

note = "Funding Information: This researchw as supportedb y NIH Grants 5-P50-AG05138-02a nd AG02219t o E.M.L. and a VA Merit grantt o R.D.B.",

year = "1990",

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doi = "10.1016/0304-3940(90)90835-W",

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T1 - Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus

AU - Blitzer, Robert D.

AU - Gil, Orlando

AU - Landau, Emmanuel M.

N1 - Funding Information: This researchw as supportedb y NIH Grants 5-P50-AG05138-02a nd AG02219t o E.M.L. and a VA Merit grantt o R.D.B.

PY - 1990/11/13

Y1 - 1990/11/13

N2 - The effect of the cholinergic agonist carbachol on a putative substrate for memory (long-term potentiation; LTP) was investigated in slices of rat hippocampus (CA1 region). Carbachol (5 μM) increased LTP when the presynaptic depression of the EPSP was controlled. The results indicate that carbachol enhances the effectiveness of the tetanus, probably through postsynaptic mechanisms. This effect may have implications for the role of acetylcholine in memory and the use of cholinergics in memory disorders.

AB - The effect of the cholinergic agonist carbachol on a putative substrate for memory (long-term potentiation; LTP) was investigated in slices of rat hippocampus (CA1 region). Carbachol (5 μM) increased LTP when the presynaptic depression of the EPSP was controlled. The results indicate that carbachol enhances the effectiveness of the tetanus, probably through postsynaptic mechanisms. This effect may have implications for the role of acetylcholine in memory and the use of cholinergics in memory disorders.

KW - Acetylcholine

KW - Carbachol

KW - Hippocampus

KW - Long-term potentiation

KW - Rat

KW - Synaptic plasticity

UR - https://www.scopus.com/pages/publications/0025081430

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DO - 10.1016/0304-3940(90)90835-W

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AN - SCOPUS:0025081430

SN - 0304-3940

VL - 119

SP - 207

EP - 210

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus

Abstract

Keywords

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