Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor

Joseph D. Buxbaum; Masaki Oishi; Henry I. Chen; Ronit Pinkas-Kramarski; Eric A. Jaffe; Samuel E. Gandy; Paul Greengard

doi:10.1073/pnas.89.21.10075

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor

Joseph D. Buxbaum, Masaki Oishi, Henry I. Chen, Ronit Pinkas-Kramarski, Eric A. Jaffe, Samuel E. Gandy, Paul Greengard

Research output: Contribution to journal › Article › peer-review

526 Scopus citations

Abstract

Activation of protein kinase C by phorbol esters is known to accelerate the processing and secretion of the β/A4 amyloid protein precursor. We have now examined various first messengers that increase protein kinase C activity of target cells for their ability to affect β/A4 amyloid protein precursor metabolism. Acetylcholine and interleukin 1, which are altered in Alzheimer disease, were shown to increase processing of the β/A4 amyloid protein precursor via the secretory cleavage pathway. Cholinergic agonists stimulated secretion in human glioma and neuroblastoma cells as well as in PC 12 cells transfected with the MI receptor, while interleukin 1 stimulated secretion in human endothelial and glioma cells.

Original language	English
Pages (from-to)	10075-10078
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	89
Issue number	21
DOIs	https://doi.org/10.1073/pnas.89.21.10075
State	Published - 1992
Externally published	Yes

Keywords

Dementia
Protein kinase
Protein phosphorylation
Proteolysis

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Buxbaum, J. D., Oishi, M., Chen, H. I., Pinkas-Kramarski, R., Jaffe, E. A., Gandy, S. E., & Greengard, P. (1992). Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor. Proceedings of the National Academy of Sciences of the United States of America, 89(21), 10075-10078. https://doi.org/10.1073/pnas.89.21.10075

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title = "Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor",

abstract = "Activation of protein kinase C by phorbol esters is known to accelerate the processing and secretion of the β/A4 amyloid protein precursor. We have now examined various first messengers that increase protein kinase C activity of target cells for their ability to affect β/A4 amyloid protein precursor metabolism. Acetylcholine and interleukin 1, which are altered in Alzheimer disease, were shown to increase processing of the β/A4 amyloid protein precursor via the secretory cleavage pathway. Cholinergic agonists stimulated secretion in human glioma and neuroblastoma cells as well as in PC 12 cells transfected with the MI receptor, while interleukin 1 stimulated secretion in human endothelial and glioma cells.",

keywords = "Dementia, Protein kinase, Protein phosphorylation, Proteolysis",

author = "Buxbaum, {Joseph D.} and Masaki Oishi and Chen, {Henry I.} and Ronit Pinkas-Kramarski and Jaffe, {Eric A.} and Gandy, {Samuel E.} and Paul Greengard",

year = "1992",

doi = "10.1073/pnas.89.21.10075",

language = "English",

volume = "89",

pages = "10075--10078",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

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publisher = "National Academy of Sciences",

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}

Buxbaum, JD, Oishi, M, Chen, HI, Pinkas-Kramarski, R, Jaffe, EA, Gandy, SE & Greengard, P 1992, 'Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor', Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 21, pp. 10075-10078. https://doi.org/10.1073/pnas.89.21.10075

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor. / Buxbaum, Joseph D.; Oishi, Masaki; Chen, Henry I. et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, No. 21, 1992, p. 10075-10078.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor

AU - Buxbaum, Joseph D.

AU - Oishi, Masaki

AU - Chen, Henry I.

AU - Pinkas-Kramarski, Ronit

AU - Jaffe, Eric A.

AU - Gandy, Samuel E.

AU - Greengard, Paul

PY - 1992

Y1 - 1992

N2 - Activation of protein kinase C by phorbol esters is known to accelerate the processing and secretion of the β/A4 amyloid protein precursor. We have now examined various first messengers that increase protein kinase C activity of target cells for their ability to affect β/A4 amyloid protein precursor metabolism. Acetylcholine and interleukin 1, which are altered in Alzheimer disease, were shown to increase processing of the β/A4 amyloid protein precursor via the secretory cleavage pathway. Cholinergic agonists stimulated secretion in human glioma and neuroblastoma cells as well as in PC 12 cells transfected with the MI receptor, while interleukin 1 stimulated secretion in human endothelial and glioma cells.

AB - Activation of protein kinase C by phorbol esters is known to accelerate the processing and secretion of the β/A4 amyloid protein precursor. We have now examined various first messengers that increase protein kinase C activity of target cells for their ability to affect β/A4 amyloid protein precursor metabolism. Acetylcholine and interleukin 1, which are altered in Alzheimer disease, were shown to increase processing of the β/A4 amyloid protein precursor via the secretory cleavage pathway. Cholinergic agonists stimulated secretion in human glioma and neuroblastoma cells as well as in PC 12 cells transfected with the MI receptor, while interleukin 1 stimulated secretion in human endothelial and glioma cells.

KW - Dementia

KW - Protein kinase

KW - Protein phosphorylation

KW - Proteolysis

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DO - 10.1073/pnas.89.21.10075

M3 - Article

C2 - 1359534

AN - SCOPUS:0026448114

SN - 0027-8424

VL - 89

SP - 10075

EP - 10078

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 21

ER -

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor

Abstract

Keywords

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