Cholesterol and Coronary Heart: Disease Risk in Elderly Patients

Thomas Stamos, Robert S. Rosenson

Research output: Contribution to journalLetterpeer-review

2 Scopus citations


In an article in the November 2,1994, issue of The Journal, Dr Krumholz and colleagues1 prospectively followed 997 elderly subjects and reported no significant relationship between total cholesterol or high-density lipoprotein cholesterol (HDL-C) and cardiac events. Because the wide confidence intervals (CIs) included values greater than 1.0, this cannot be considered a negative study. In fact, the upper limit of their CI for adjusted CHD mortality for men and women (1.98) is a similar risk ratio to that reported previously in middle-aged men.2 Part of the reason for the wide CIs is likely the size of the study and short duration of follow-up. Studies establishing the relationship between hypercholesterolemia and CHD in middle-aged individuals evaluated many more subjects for greater lengths of time.

Original languageEnglish
Pages (from-to)1330
Number of pages1
JournalJAMA - Journal of the American Medical Association
Issue number17
StatePublished - May 1995
Externally publishedYes


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