TY - JOUR
T1 - Cholesterol and Coronary Heart
T2 - Disease Risk in Elderly Patients
AU - Stamos, Thomas
AU - Rosenson, Robert S.
PY - 1995/5
Y1 - 1995/5
N2 - In an article in the November 2,1994, issue of The Journal, Dr Krumholz and colleagues1 prospectively followed 997 elderly subjects and reported no significant relationship between total cholesterol or high-density lipoprotein cholesterol (HDL-C) and cardiac events. Because the wide confidence intervals (CIs) included values greater than 1.0, this cannot be considered a negative study. In fact, the upper limit of their CI for adjusted CHD mortality for men and women (1.98) is a similar risk ratio to that reported previously in middle-aged men.2 Part of the reason for the wide CIs is likely the size of the study and short duration of follow-up. Studies establishing the relationship between hypercholesterolemia and CHD in middle-aged individuals evaluated many more subjects for greater lengths of time.
AB - In an article in the November 2,1994, issue of The Journal, Dr Krumholz and colleagues1 prospectively followed 997 elderly subjects and reported no significant relationship between total cholesterol or high-density lipoprotein cholesterol (HDL-C) and cardiac events. Because the wide confidence intervals (CIs) included values greater than 1.0, this cannot be considered a negative study. In fact, the upper limit of their CI for adjusted CHD mortality for men and women (1.98) is a similar risk ratio to that reported previously in middle-aged men.2 Part of the reason for the wide CIs is likely the size of the study and short duration of follow-up. Studies establishing the relationship between hypercholesterolemia and CHD in middle-aged individuals evaluated many more subjects for greater lengths of time.
UR - http://www.scopus.com/inward/record.url?scp=0029634259&partnerID=8YFLogxK
U2 - 10.1001/jama.1995.03520410023010
DO - 10.1001/jama.1995.03520410023010
M3 - Letter
C2 - 7772166
AN - SCOPUS:0029634259
SN - 0098-7484
VL - 273
SP - 1330
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
IS - 17
ER -