Cholestatic Jaundice

James K. O'donnell, Robert P. Yatto, Jerome H. Siegel, David S. Zimmon, Arthur R. Clemett, Avram M. Cooperman, Jerome F. Wiot, Robert A. Clark, Bruce F. Scharschmidt

Research output: Contribution to journalLetterpeer-review


To the Editor: The review by Scharschmidt et al. of approaches to the patient with cholestatic jaundice (June 23 issue)1 is inaccurate in its dismissal of cholescintigraphy as a routine procedure in the evaluation of these patients. The papers cited to document the shortcomings of radioisotope techniques2 3 4 use data from studies performed before 1981 with technetium-99m-iminodiacetic acid analogues now considered suboptimal for imaging in patients with elevated serum bilirubin. Most institutions now use technetium-99m disofenin as the radiopharmaceutical of choice, since it has been shown to give diagnostic results despite bilirubin levels approaching 40 mg per 100 ml.5,6 In addition,.

Original languageEnglish
Pages (from-to)1191-1193
Number of pages3
JournalNew England Journal of Medicine
Issue number19
StatePublished - 10 Nov 1983
Externally publishedYes


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