Cholecystokinin in anxiety

Harold J.G.M. Van Megen; Herman G.M. Westenberg; Johan A. Den Boer; René S. Kahn

doi:10.1016/S0924-977X(96)00038-7

Cholecystokinin in anxiety

Harold J.G.M. Van Megen
, Herman G.M. Westenberg
, Johan A. Den Boer
, René S. Kahn

Research output: Contribution to journal › Review article › peer-review

113 Scopus citations

Abstract

Cholecystokinin (CCK) plays an important role in both the alimentary tract and the central nervous system (CNS). At present it seems to be the most abundant neuropeptide in the CNS. This paper reviews the CCK neuronal system and its interactions with γ-aminobutyric acid (GABA) and serotonin (5-hydroxytryptamine; 5-HT). In addition, its putative role in anxiety will be discussed on the basis of animal data and studies in healthy volunteers and panic disorder patients. According to these investigations, the CCK₄ challenge test fulfills most criteria for an ideal panicogenic agent and evidence has been found that CCK(B) receptor antagonists might possess anxiolytic proprrties in man.

Original language	English
Pages (from-to)	263-280
Number of pages	18
Journal	European Neuropsychopharmacology
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/S0924-977X(96)00038-7
State	Published - Nov 1996
Externally published	Yes

Keywords

CCK
animal studies
anxiety
human studies
neuropeptides

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10.1016/S0924-977X(96)00038-7

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title = "Cholecystokinin in anxiety",

abstract = "Cholecystokinin (CCK) plays an important role in both the alimentary tract and the central nervous system (CNS). At present it seems to be the most abundant neuropeptide in the CNS. This paper reviews the CCK neuronal system and its interactions with γ-aminobutyric acid (GABA) and serotonin (5-hydroxytryptamine; 5-HT). In addition, its putative role in anxiety will be discussed on the basis of animal data and studies in healthy volunteers and panic disorder patients. According to these investigations, the CCK4 challenge test fulfills most criteria for an ideal panicogenic agent and evidence has been found that CCK(B) receptor antagonists might possess anxiolytic proprrties in man.",

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author = "\{Van Megen\}, \{Harold J.G.M.\} and Westenberg, \{Herman G.M.\} and \{Den Boer\}, \{Johan A.\} and Kahn, \{Ren{\'e} S.\}",

year = "1996",

month = nov,

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language = "English",

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T1 - Cholecystokinin in anxiety

AU - Van Megen, Harold J.G.M.

AU - Westenberg, Herman G.M.

AU - Den Boer, Johan A.

AU - Kahn, René S.

PY - 1996/11

Y1 - 1996/11

N2 - Cholecystokinin (CCK) plays an important role in both the alimentary tract and the central nervous system (CNS). At present it seems to be the most abundant neuropeptide in the CNS. This paper reviews the CCK neuronal system and its interactions with γ-aminobutyric acid (GABA) and serotonin (5-hydroxytryptamine; 5-HT). In addition, its putative role in anxiety will be discussed on the basis of animal data and studies in healthy volunteers and panic disorder patients. According to these investigations, the CCK4 challenge test fulfills most criteria for an ideal panicogenic agent and evidence has been found that CCK(B) receptor antagonists might possess anxiolytic proprrties in man.

AB - Cholecystokinin (CCK) plays an important role in both the alimentary tract and the central nervous system (CNS). At present it seems to be the most abundant neuropeptide in the CNS. This paper reviews the CCK neuronal system and its interactions with γ-aminobutyric acid (GABA) and serotonin (5-hydroxytryptamine; 5-HT). In addition, its putative role in anxiety will be discussed on the basis of animal data and studies in healthy volunteers and panic disorder patients. According to these investigations, the CCK4 challenge test fulfills most criteria for an ideal panicogenic agent and evidence has been found that CCK(B) receptor antagonists might possess anxiolytic proprrties in man.

KW - CCK

KW - animal studies

KW - anxiety

KW - human studies

KW - neuropeptides

UR - https://www.scopus.com/pages/publications/0030294164

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DO - 10.1016/S0924-977X(96)00038-7

M3 - Review article

C2 - 8985709

AN - SCOPUS:0030294164

SN - 0924-977X

VL - 6

SP - 263

EP - 280

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

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ER -

Cholecystokinin in anxiety

Abstract

Keywords

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