Cholangitis Associated With Cryptococcus neoformans

John C. Bucuvalas, Kevin E. Bove, Robert A. Kaufman, Mary J.R. Gilchrist, Keith T. Oldham, William F. Balistreri

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


A 15-yr-old girl presented with complaints of right upper quadrant pain and jaundice. Elevation of serum alkaline phosphatase, signs of portal hypertension, and computed tomographic scan findings suggested a diagnosis of primary sclerosing cholangitis. However, cultures of the bile and of the common bile duct specimen obtained during a surgical procedure grew Cryptococcus neof ormans. Treatment with amphotericin B was begun. An episode of upper gastrointestinal bleeding, however, led to the hepatorenal syndrome, and the patient died before anti f ungal therapy was completed. At autopsy, active sclerosing cholangitis associated with cryptococci involved the common bile duct. We suggest that opportunistic infection of the biliary tree should be considered in pediatric patients with presumed primary sclerosing cholangitis.

Original languageEnglish
Pages (from-to)1055-1059
Number of pages5
Issue number4
StatePublished - 1985
Externally publishedYes


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