TY - JOUR
T1 - Chinese herbal therapy for the treatment of food allergy
AU - Wang, Julie
AU - Li, Xiu Min
N1 - Funding Information:
Xiu-Min Li, MD is funded in part by grants from the National Institutes of Health/National Center for Complementary and Alternative Medicine (1R01AT001495-01A1 and 2R01AT001495-05A1), Food Allergy Initiative, and the Winston Wolkoff Integrative Medicine for Allergy and Immunology Foundation.
Funding Information:
Acknowledgments Julie Wang, MD is funded in part by a grant from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (K23 AI083883).
PY - 2012/8
Y1 - 2012/8
N2 - Traditional Chinese medicine (TCM) has been widely used in China to treat various diseases for thousands of years. Given its reputed effectiveness, low cost, and favorable safety profile, TCM is attracting great interest in Western societies as a source of therapy for an array of illnesses, including allergies and asthma. Although food allergy has not been described in the TCM literature, a novel treatment for food allergy, named the food allergy herbal formula-2 (FAHF-2), was developed using TCM principles. Using a well-characterized murine model of peanut allergy, FAHF-2 has been shown to be highly effective in providing long-term protection against peanut-induced anaphylaxis, with a high safety margin. Phase 1 human trials have demonstrated the safety of FAHF-2 in food allergic individuals. Currently, a phase 2 trial examining efficacy of FAHF-2 is on-going. Other TCMs also show a potential for treating food allergies in preclinical studies.
AB - Traditional Chinese medicine (TCM) has been widely used in China to treat various diseases for thousands of years. Given its reputed effectiveness, low cost, and favorable safety profile, TCM is attracting great interest in Western societies as a source of therapy for an array of illnesses, including allergies and asthma. Although food allergy has not been described in the TCM literature, a novel treatment for food allergy, named the food allergy herbal formula-2 (FAHF-2), was developed using TCM principles. Using a well-characterized murine model of peanut allergy, FAHF-2 has been shown to be highly effective in providing long-term protection against peanut-induced anaphylaxis, with a high safety margin. Phase 1 human trials have demonstrated the safety of FAHF-2 in food allergic individuals. Currently, a phase 2 trial examining efficacy of FAHF-2 is on-going. Other TCMs also show a potential for treating food allergies in preclinical studies.
KW - Allergy
KW - Chinese herbal medicine
KW - Food
KW - Food allergy herbal formula-2
KW - Therapy FAHF-2
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=84865590649&partnerID=8YFLogxK
U2 - 10.1007/s11882-012-0265-4
DO - 10.1007/s11882-012-0265-4
M3 - Article
C2 - 22581122
AN - SCOPUS:84865590649
SN - 1529-7322
VL - 12
SP - 332
EP - 338
JO - Current Allergy and Asthma Reports
JF - Current Allergy and Asthma Reports
IS - 4
ER -