Chimeric antigen receptor engineered T cells can eliminate brain tumors and initiate long-term protection against recurrence

Laura A. Johnson, Luis Sanchez-Perez, Carter M. Suryadevara, John H. Sampson

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

CAR therapy has shown promise in treating cancer, but at the cost of unexpected toxicity against normal tissues, not predicted by preclinical testing. We are working to generate more physiologically relevant models for preclinical CAR toxicity testing, and in doing so, have discovered that CAR therapy induces immunogenic cell death, with the potential for cures.

Original languageEnglish
Article numbere944059
JournalOncoImmunology
Volume3
Issue number7
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Adoptive cell therapy
  • Cancer immunology
  • Chimeric antigen receptor
  • Gene-engineering
  • Glioblastoma
  • Tumor immunotherapy

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