Children's Oncology Group's 2023 blueprint for research: Cellular therapy and stem cell transplantation

Carrie L. Kitko, Catherine M. Bollard, Mitchell S. Cairo, Joseph Chewning, Terry J. Fry, Michael A. Pulsipher, Shalini Shenoy, Donna A. Wall, John E. Levine

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Since the publication of the last Cellular Therapy and Stem Cell Transplant blueprint in 2013, Children's Oncology Group cellular therapy-based trials advanced the field and created new standards of care across a wide spectrum of pediatric cancer diagnoses. Key findings include that tandem autologous transplant improved survival for patients with neuroblastoma and atypical teratoid/rhabdoid brain tumors, one umbilical cord blood (UCB) donor was safer than two UCB donors, killer immunoglobulin receptor (KIR) mismatched donors did not improve survival for pediatric acute myeloid leukemia when in vivo T-cell depletion is used, and the depth of remission as measured by next-generation sequencing-based minimal residual disease assessment pretransplant was the best predictor of relapse for acute lymphoblastic leukemia. Plans for the next decade include optimizing donor selection for transplants for acute leukemia/myelodysplastic syndrome, using novel engineered cellular therapies to target a wide array of malignancies, and developing better treatments for cellular therapy toxicities such as viral infections and graft-vs-host disease.

Original languageEnglish
Article numbere30577
JournalPediatric Blood and Cancer
Volume70
Issue numberS6
DOIs
StatePublished - Sep 2023

Keywords

  • ALL
  • AML
  • BMT
  • CNS tumors
  • neuroblastoma

Fingerprint

Dive into the research topics of 'Children's Oncology Group's 2023 blueprint for research: Cellular therapy and stem cell transplantation'. Together they form a unique fingerprint.

Cite this