TY - JOUR
T1 - Children's oncology group AALL0434
T2 - A phase III randomized clinical trial testing nelarabine in newly diagnosed t-cell acute lymphoblastic leukemia
AU - Dunsmore, Kimberly P.
AU - Winter, Stuart S.
AU - Devidas, Meenakshi
AU - Wood, Brent L.
AU - Esiashvili, Natia
AU - Chen, Zhiguo
AU - Eisenberg, Nancy
AU - Briegel, Nikki
AU - Hayashi, Robert J.
AU - Gastier-Foster, Julie M.
AU - Carroll, Andrew J.
AU - Heerema, Nyla A.
AU - Asselin, Barbara L.
AU - Rabin, Karen R.
AU - Zweidler-Mckay, Patrick A.
AU - Raetz, Elizabeth A.
AU - Loh, Mignon L.
AU - Schultz, Kirk R.
AU - Winick, Naomi J.
AU - Carroll, William L.
AU - Hunger, Stephen P.
N1 - Publisher Copyright:
© 2020 by American Society of Clinical Oncology.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - PURPOSE Nelarabine is effective in inducing remission in patients with relapsed and refractory T-cell acute lymphoblastic leukemia (T-ALL) but has not been fully evaluated in those with newly diagnosed disease. PATIENTS AND METHODS From 2007 to 2014, Children's Oncology Group trial AALL0434 (ClinicalTrials.gov identifier: NCT00408005) enrolled 1,562 evaluable patients with T-ALL age 1-31 years who received the augmented Berlin-Frankfurt-Muenster (ABFM) regimen with a 2 × 2 pseudo-factorial randomization to receive escalating-dose methotrexate (MTX) without leucovorin rescue plus pegaspargase (C-MTX) or high-dose MTX (HDMTX) with leucovorin rescue. Intermediate- and high-risk patients were also randomly assigned after induction to receive or not receive six 5-day courses of nelarabine that was incorporated into ABFM. Patients who experienced induction failure were nonrandomly assigned to HDMTX plus nelarabine. Patients with overt CNS disease (CNS3; ≥ 5 WBCs/mL with blasts) received HDMTX and were randomly assigned to receive or not receive nelarabine. All patients, except those with low-risk disease, received cranial irradiation. RESULTS The 5-year event-free and overall survival rates were 83.7%±1.1% and 89.5% ±0.9%, respectively. The 5-year disease-free survival (DFS) rates for patients with T-ALL randomly assigned to nelarabine (n 5 323) and no nelarabine (n = 336) were 88.2% ± 2.4% and 82.1% ± 2.7%, respectively (P =029). Differences between DFS in a four-arm comparison were significant (P =01), with no interactions between the MTX and nelarabine randomizations (P =41). Patients treated with the best-performing arm, C-MTX plus nelarabine, had a 5-year DFS of 91% (n =147). Patients who received nelarabine had significantly fewer isolated and combined CNS relapses compared with patients who did not receive nelarabine (1.3% ±0.63% v 6.9% ±1.4%, respectively; P 5 .0001). Toxicities, including neurotoxicity, were acceptable and similar between all four arms. CONCLUSION The addition of nelarabine to ABFM therapy improved DFS for children and young adults with newly diagnosed T-ALL without increased toxicity.
AB - PURPOSE Nelarabine is effective in inducing remission in patients with relapsed and refractory T-cell acute lymphoblastic leukemia (T-ALL) but has not been fully evaluated in those with newly diagnosed disease. PATIENTS AND METHODS From 2007 to 2014, Children's Oncology Group trial AALL0434 (ClinicalTrials.gov identifier: NCT00408005) enrolled 1,562 evaluable patients with T-ALL age 1-31 years who received the augmented Berlin-Frankfurt-Muenster (ABFM) regimen with a 2 × 2 pseudo-factorial randomization to receive escalating-dose methotrexate (MTX) without leucovorin rescue plus pegaspargase (C-MTX) or high-dose MTX (HDMTX) with leucovorin rescue. Intermediate- and high-risk patients were also randomly assigned after induction to receive or not receive six 5-day courses of nelarabine that was incorporated into ABFM. Patients who experienced induction failure were nonrandomly assigned to HDMTX plus nelarabine. Patients with overt CNS disease (CNS3; ≥ 5 WBCs/mL with blasts) received HDMTX and were randomly assigned to receive or not receive nelarabine. All patients, except those with low-risk disease, received cranial irradiation. RESULTS The 5-year event-free and overall survival rates were 83.7%±1.1% and 89.5% ±0.9%, respectively. The 5-year disease-free survival (DFS) rates for patients with T-ALL randomly assigned to nelarabine (n 5 323) and no nelarabine (n = 336) were 88.2% ± 2.4% and 82.1% ± 2.7%, respectively (P =029). Differences between DFS in a four-arm comparison were significant (P =01), with no interactions between the MTX and nelarabine randomizations (P =41). Patients treated with the best-performing arm, C-MTX plus nelarabine, had a 5-year DFS of 91% (n =147). Patients who received nelarabine had significantly fewer isolated and combined CNS relapses compared with patients who did not receive nelarabine (1.3% ±0.63% v 6.9% ±1.4%, respectively; P 5 .0001). Toxicities, including neurotoxicity, were acceptable and similar between all four arms. CONCLUSION The addition of nelarabine to ABFM therapy improved DFS for children and young adults with newly diagnosed T-ALL without increased toxicity.
UR - http://www.scopus.com/inward/record.url?scp=85091891037&partnerID=8YFLogxK
U2 - 10.1200/JCO.20.00256
DO - 10.1200/JCO.20.00256
M3 - Article
C2 - 32813610
AN - SCOPUS:85091891037
SN - 0732-183X
VL - 38
SP - 3282
EP - 3293
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 28
ER -