TY - JOUR
T1 - Childhood trauma and emotional processing circuits in schizophrenia
T2 - A functional connectivity study
AU - Cancel, Aïda
AU - Comte, Magali
AU - Boutet, Claire
AU - Schneider, Fabien C.
AU - Rousseau, Pierre François
AU - Boukezzi, Sarah
AU - Gay, Aurélia
AU - Sigaud, Torrance
AU - Massoubre, Catherine
AU - Berna, Fabrice
AU - Zendjidjian, Xavier Y.
AU - Azorin, Jean Michel
AU - Blin, Olivier
AU - Fakra, Eric
N1 - Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2017/6
Y1 - 2017/6
N2 - Childhood trauma strongly impacts emotional responses in schizophrenia. We have explored an association between early trauma and the amygdala functional connectivity using generalized psychophysiological interaction during an emotional task. Twenty-one schizophrenia patients and twenty-five controls were included. In schizophrenia patients, higher levels of sexual abuse and physical neglect during childhood were associated with decreased connectivity between the amygdala and the posterior cingulate/precuneus region. Additionally, patients showed decreased coupling between the amygdala and the posterior cingulate/precuneus region compared to controls. These findings suggest that early trauma could impact later connectivity in specific stress-related circuits affecting self-consciousness and social cognition in schizophrenia.
AB - Childhood trauma strongly impacts emotional responses in schizophrenia. We have explored an association between early trauma and the amygdala functional connectivity using generalized psychophysiological interaction during an emotional task. Twenty-one schizophrenia patients and twenty-five controls were included. In schizophrenia patients, higher levels of sexual abuse and physical neglect during childhood were associated with decreased connectivity between the amygdala and the posterior cingulate/precuneus region. Additionally, patients showed decreased coupling between the amygdala and the posterior cingulate/precuneus region compared to controls. These findings suggest that early trauma could impact later connectivity in specific stress-related circuits affecting self-consciousness and social cognition in schizophrenia.
KW - Amygdala
KW - Childhood trauma
KW - Posterior cingulate cortex
KW - Precuneus
KW - Schizophrenia
KW - fMRI functional connectivity
UR - https://www.scopus.com/pages/publications/85008156683
U2 - 10.1016/j.schres.2016.12.003
DO - 10.1016/j.schres.2016.12.003
M3 - Article
C2 - 27979699
AN - SCOPUS:85008156683
SN - 0920-9964
VL - 184
SP - 69
EP - 72
JO - Schizophrenia Research
JF - Schizophrenia Research
ER -