ChEpiMod: A knowledgebase for chemical modulators of epigenome reader domains

Jamel Meslamani; Steven G. Smith; Roberto Sanchez; Ming Ming Zhou

doi:10.1093/bioinformatics/btu052

ChEpiMod: A knowledgebase for chemical modulators of epigenome reader domains

Jamel Meslamani
, Steven G. Smith
, Roberto Sanchez
, Ming Ming Zhou

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Context: Epigenome reader domains are rapidly emerging as a new class of drug targets for a wide array of human diseases. To facilitate study of structure-activity relationship and small-molecule ligand design for these domains, we have created ChEpiMod. ChEpiMod is a free knowledgebase of chemical modulators with documented modulatory activity for epigenome reader domains. Methods: ChEpiMod organizes information about chemical modulators and their associated binding-affinity data, as well as available structures of epigenome readers from the Protein Data Bank. The data are gathered from the literature and patents. Entries are supplemented by annotation. The current version of ChEpiMod covers six epigenome reader domain families (Bromodomain, PHD finger, Chromodomain, MBT, PWWP and Tudor). The database can be used to browse existing chemical modulators and bioactivity data, as well as, all available structures of readers and their molecular interactions. The database is updated weekly.

Original language	English
Pages (from-to)	1481-1483
Number of pages	3
Journal	Bioinformatics
Volume	30
Issue number	10
DOIs	https://doi.org/10.1093/bioinformatics/btu052
State	Published - 15 May 2014

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10.1093/bioinformatics/btu052

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title = "ChEpiMod: A knowledgebase for chemical modulators of epigenome reader domains",

abstract = "Context: Epigenome reader domains are rapidly emerging as a new class of drug targets for a wide array of human diseases. To facilitate study of structure-activity relationship and small-molecule ligand design for these domains, we have created ChEpiMod. ChEpiMod is a free knowledgebase of chemical modulators with documented modulatory activity for epigenome reader domains. Methods: ChEpiMod organizes information about chemical modulators and their associated binding-affinity data, as well as available structures of epigenome readers from the Protein Data Bank. The data are gathered from the literature and patents. Entries are supplemented by annotation. The current version of ChEpiMod covers six epigenome reader domain families (Bromodomain, PHD finger, Chromodomain, MBT, PWWP and Tudor). The database can be used to browse existing chemical modulators and bioactivity data, as well as, all available structures of readers and their molecular interactions. The database is updated weekly.",

author = "Jamel Meslamani and Smith, \{Steven G.\} and Roberto Sanchez and Zhou, \{Ming Ming\}",

note = "Funding Information: Funding: This work was funded in part by the research grants from the National Institutes of Health (HG004508 and CA87658 to M.-M.Z.)",

year = "2014",

month = may,

day = "15",

doi = "10.1093/bioinformatics/btu052",

language = "English",

volume = "30",

pages = "1481--1483",

journal = "Bioinformatics",

issn = "1367-4803",

publisher = "Oxford University Press",

number = "10",

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TY - JOUR

T1 - ChEpiMod

T2 - A knowledgebase for chemical modulators of epigenome reader domains

AU - Meslamani, Jamel

AU - Smith, Steven G.

AU - Sanchez, Roberto

AU - Zhou, Ming Ming

N1 - Funding Information: Funding: This work was funded in part by the research grants from the National Institutes of Health (HG004508 and CA87658 to M.-M.Z.)

PY - 2014/5/15

Y1 - 2014/5/15

N2 - Context: Epigenome reader domains are rapidly emerging as a new class of drug targets for a wide array of human diseases. To facilitate study of structure-activity relationship and small-molecule ligand design for these domains, we have created ChEpiMod. ChEpiMod is a free knowledgebase of chemical modulators with documented modulatory activity for epigenome reader domains. Methods: ChEpiMod organizes information about chemical modulators and their associated binding-affinity data, as well as available structures of epigenome readers from the Protein Data Bank. The data are gathered from the literature and patents. Entries are supplemented by annotation. The current version of ChEpiMod covers six epigenome reader domain families (Bromodomain, PHD finger, Chromodomain, MBT, PWWP and Tudor). The database can be used to browse existing chemical modulators and bioactivity data, as well as, all available structures of readers and their molecular interactions. The database is updated weekly.

AB - Context: Epigenome reader domains are rapidly emerging as a new class of drug targets for a wide array of human diseases. To facilitate study of structure-activity relationship and small-molecule ligand design for these domains, we have created ChEpiMod. ChEpiMod is a free knowledgebase of chemical modulators with documented modulatory activity for epigenome reader domains. Methods: ChEpiMod organizes information about chemical modulators and their associated binding-affinity data, as well as available structures of epigenome readers from the Protein Data Bank. The data are gathered from the literature and patents. Entries are supplemented by annotation. The current version of ChEpiMod covers six epigenome reader domain families (Bromodomain, PHD finger, Chromodomain, MBT, PWWP and Tudor). The database can be used to browse existing chemical modulators and bioactivity data, as well as, all available structures of readers and their molecular interactions. The database is updated weekly.

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SN - 1367-4803

VL - 30

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EP - 1483

JO - Bioinformatics

JF - Bioinformatics

IS - 10

ER -

ChEpiMod: A knowledgebase for chemical modulators of epigenome reader domains

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