Chemotherapy‐induced alterations in the biomechanics of rat bone

Richard R. Pelker, Gary E. Friedlaender, Manohar M. Panjabi, Thomas Markham, Michael Hausman, Andrew C. Doganis, Jim McKay

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38 Scopus citations


The effects of methotrexate and doxorubicin (Adriamycin) on intact and fractured bone were studied in a rat model. Methotrexate, 0.1 mg/kg i.p., was administered five times a week, or doxorubicin, 1 mg/kg i.v., was given once a week. Animals were killed and evaluated at 4, 8, 12, and 16 weeks after surgical production of a unilateral femoral osteotomy and initiation of the chemotherapeuitic program. Both intact and fractured bones were tested to failure in rapid torsion, and the torque, angular deformation, stiffness, and energy were measured. There was a significant alteration in the strength of the healing osteotomies in doxorubicin‐ and methotrexate‐treated animals compared with the control group. The torsional strength of intact bone was not significantly altered by either drug protocol over the period of this observation.

Original languageEnglish
Pages (from-to)91-95
Number of pages5
JournalJournal of Orthopaedic Research
Issue number1
StatePublished - 1985
Externally publishedYes


  • Biomechanics
  • Chemotherapy
  • Doxorubicin (Adriamycin)
  • Fracture healing
  • Methotrexate


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