Chemotherapy of the leukemic transformation of lymphosarcoma

Barbara Jones, Faith Kung, William L. Nyhan, Juliet Hananian, Johannes Blom, E. Omer Burgert, S. D. Mills, Carmen Treat, Irving J. Wolman, Louise Chevalier, Ronald Denton, Paul Sheehe, Oliver Glidewell, James F. Holland

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The chemotherapy of leukemic transformation of lymphosarcoma has been studied in seventeen children. Complete hematologic remission was obtained in 88 per cent treated with 6-mercaptopurine and prednisone. Maintenance therapy with 6-mercaptopurine was employed and the median duration of remission was 21 weeks. These results are comparable to those obtained in a series of children with acute lymphocytic leukemia in which the remission rate was 82 per cent and median duration of remissoin was 33 weeks with the same therapy.

Original languageEnglish
Pages (from-to)442-448
Number of pages7
JournalJournal of Pediatrics
Volume70
Issue number3 PART 1
DOIs
StatePublished - Mar 1967
Externally publishedYes

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