Chemotherapy-induced Parkinsonism responsive to levodopa: An underrecognized entity

Cathy Chuang, Anne Constantino, Casilda Balmaceda, David Eidelberg, Steven J. Frucht

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Parkinsonism is a rare neurological complication of cancer treatment. Although individual case reports of this syndrome have been reported, the clinical features and prevalence of this syndrome are unknown. We present 3 patients, encountered over 6 months at one institution, who developed parkinsonism after treatment with various chemotherapeutic agents. Parkinsonism was severe in 2 patients, affecting postural reflexes, speech, and swallowing. All 3 patients responded dramatically to treatment with levodopa, and parkinsonism spontaneously improved or remitted over months. This unusual complication of cancer therapy is treatable and may be underappreciated.

Original languageEnglish
Pages (from-to)328-331
Number of pages4
JournalMovement Disorders
Issue number3
StatePublished - 1 Mar 2003
Externally publishedYes


  • Chemotherapy
  • Levodopa
  • Pakinsonism


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