TY - JOUR
T1 - Chemotherapy for gynecologic cancers
AU - Rahaman, Jamal
AU - Steiner, Norma
AU - Hayes, Monica Prasad
AU - Chuang, Linus
AU - Fishman, David
AU - Gretz, Herbert
PY - 2009/12
Y1 - 2009/12
N2 - This review highlights significant recent developments and trends in chemotherapy for major gynecologic malignancies, i.e., ovarian cancer, endometrial cancer, uterine sarcomas, gestational trophoblastic neoplasia, and cervical cancer. In ovarian cancer, chemotherapeutic options for early, advanced and recurrent disease are in the adjuvant setting as well as in the neoadjuvant setting are explored. For uterine cancer, adjuvant chemotherapy is employed for high risk epithelial subtypes with early disease, such as uterine papillary serous carcinomas, uterine carcinosarcomas and leiomyosarcomas, advanced stage cases, as well as recurrent disease. The review then proceeds to further discuss the appropriate treatment based on the International Federation of Gynecology and Obstetrics prognostic scoring system for gestational trophoblastic neoplasia. Finally, chemotherapy is utilized in cervical cancer as neoadjuvant therapy prior to surgery or radiation, as a sensitizer concomitantly with radiation therapy or for the treatment of advanced and recurrent disease.
AB - This review highlights significant recent developments and trends in chemotherapy for major gynecologic malignancies, i.e., ovarian cancer, endometrial cancer, uterine sarcomas, gestational trophoblastic neoplasia, and cervical cancer. In ovarian cancer, chemotherapeutic options for early, advanced and recurrent disease are in the adjuvant setting as well as in the neoadjuvant setting are explored. For uterine cancer, adjuvant chemotherapy is employed for high risk epithelial subtypes with early disease, such as uterine papillary serous carcinomas, uterine carcinosarcomas and leiomyosarcomas, advanced stage cases, as well as recurrent disease. The review then proceeds to further discuss the appropriate treatment based on the International Federation of Gynecology and Obstetrics prognostic scoring system for gestational trophoblastic neoplasia. Finally, chemotherapy is utilized in cervical cancer as neoadjuvant therapy prior to surgery or radiation, as a sensitizer concomitantly with radiation therapy or for the treatment of advanced and recurrent disease.
KW - Bevacizumab
KW - Cervical cancer
KW - Chemotherapy
KW - Endometrial cancer
KW - Gestational trophoblastic neoplasia
KW - Gynecological malignancies
KW - Ovarian cancer
KW - Uterine sarcoma
UR - http://www.scopus.com/inward/record.url?scp=73349115853&partnerID=8YFLogxK
U2 - 10.1002/msj.20143
DO - 10.1002/msj.20143
M3 - Review article
C2 - 20014427
AN - SCOPUS:73349115853
SN - 0027-2507
VL - 76
SP - 577
EP - 588
JO - Mount Sinai Journal of Medicine
JF - Mount Sinai Journal of Medicine
IS - 6
ER -