Chemosensitivity testing with cis-platinum(II) diamminedichloride. II. Preliminary experience in the treatment of carcinoma of the cervix

Nineteen previously untreated patients with invasive squamous cell carcinoma of the cervix were given a test dose of cis-platinum(II) diamminedichloride (DDP) prior to treatment with radiotherapy or initial surgery. Two patients who had failed radiation therapy were also tested. Histologic and cytologic characteristics in sequential cervical biopsies and clinical response were employed to determine sensitivity of tumor to platinum and to identify the patient who would most benefit from systemic platinum chemotherapy. No serious side effects were encountered. Standard treatment could be administered without unexpected toxicities or delay.