The "omic" approach to biology and drug discovery is revolutionizing the way scientists characterize an organism's molecular biology. Genomic and proteomic researchers are generating a substantial amount of data regarding the examination of molecular targets. The completion of the DNA sequence of the human genome represents a significant milestone in science. Researchers now have the ability to understand the biological mechanisms regulating human disease. Chemistry has also played an important role in this biological revolution, giving rise to the science of chemogenomics, chemical genomics, chemical biology, chemical genetics and chemoinformatics. Genomics, functional genomics and chemistry are merging into a new scientific approach known as chemogenomics. Chemogenomics involves the analysis of specific gene functions by using small chemical molecules. The employment of chemical, ligand-based methodologies is extremely useful in the high-throughput genomic and proteomic characterization of gene and protein functions. This article reviews the terminology of genomics, proteomics, bioinformatics, and especially chemogenomics. It examines the present day status and future growth of chemistry, and discusses the influence of genomic and proteomic sciences. The authors will review chemogenomics' relationship to similar disciplines and discuss how chemogenomics has already and will continue to influence molecular biology and the discovery of new drug therapies.
|Number of pages||6|
|State||Published - Mar 2004|