Chemical probes of histone lysine methyltransferases

H. Ümit Kaniskan, Jian Jin

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Growing evidence suggests that histone methyltransferases (HMTs, also known as protein methyltransferases (PMTs)) play an important role in diverse biological processes and human diseases by regulating gene expression and the chromatin state. Therefore, HMTs have been increasingly recognized by the biomedical community as a class of potential therapeutic targets. High quality chemical probes of HMTs, as tools for deciphering their physiological functions and roles in human diseases and testing therapeutic hypotheses, are critical for advancing this promising field. In this review, we focus on the discovery, characterization, and biological applications of chemical probes for HMTs.

Original languageEnglish
Pages (from-to)40-50
Number of pages11
JournalACS Chemical Biology
Issue number1
StatePublished - 16 Jan 2015


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