Chemical development of NBI-75043. Use of a flow reactor to circumvent a batch-limited metal#halogen exchange reaction

Timothy D. Gross; Shine Chou; Daniel Bonneville; Raymond S. Gross; Peng Wang; Onorato Campopiano; Michael A. Ouellette; Scott E. Zook; Jayachandra P. Reddy; Wilna J. Moree; Florence Jovic; Shubham Chopade

doi:10.1021/op800071m

Chemical development of NBI-75043. Use of a flow reactor to circumvent a batch-limited metal#halogen exchange reaction

Timothy D. Gross
, Shine Chou
, Daniel Bonneville
, Raymond S. Gross
, Peng Wang
, Onorato Campopiano
, Michael A. Ouellette
, Scott E. Zook
, Jayachandra P. Reddy
, Wilna J. Moree
, Florence Jovic
, Shubham Chopade

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The discovery route and subsequent scale-up routes for NBI-75043 are presented. When traditional batch chemistry was found to limit the scale of a key reaction, a flow reactor was designed and optimized to provide an alternate method of production.

Original language	English
Pages (from-to)	929-939
Number of pages	11
Journal	Organic Process Research and Development
Volume	12
Issue number	5
DOIs	https://doi.org/10.1021/op800071m
State	Published - 19 Sep 2008
Externally published	Yes

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Gross, T. D., Chou, S., Bonneville, D., Gross, R. S., Wang, P., Campopiano, O., Ouellette, M. A., Zook, S. E., Reddy, J. P., Moree, W. J., Jovic, F., & Chopade, S. (2008). Chemical development of NBI-75043. Use of a flow reactor to circumvent a batch-limited metal#halogen exchange reaction. Organic Process Research and Development, 12(5), 929-939. https://doi.org/10.1021/op800071m

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title = "Chemical development of NBI-75043. Use of a flow reactor to circumvent a batch-limited metal\#halogen exchange reaction",

abstract = "The discovery route and subsequent scale-up routes for NBI-75043 are presented. When traditional batch chemistry was found to limit the scale of a key reaction, a flow reactor was designed and optimized to provide an alternate method of production.",

author = "Gross, \{Timothy D.\} and Shine Chou and Daniel Bonneville and Gross, \{Raymond S.\} and Peng Wang and Onorato Campopiano and Ouellette, \{Michael A.\} and Zook, \{Scott E.\} and Reddy, \{Jayachandra P.\} and Moree, \{Wilna J.\} and Florence Jovic and Shubham Chopade",

year = "2008",

month = sep,

day = "19",

doi = "10.1021/op800071m",

language = "English",

volume = "12",

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journal = "Organic Process Research and Development",

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Gross, TD, Chou, S, Bonneville, D, Gross, RS, Wang, P, Campopiano, O, Ouellette, MA, Zook, SE, Reddy, JP, Moree, WJ, Jovic, F & Chopade, S 2008, 'Chemical development of NBI-75043. Use of a flow reactor to circumvent a batch-limited metal#halogen exchange reaction', Organic Process Research and Development, vol. 12, no. 5, pp. 929-939. https://doi.org/10.1021/op800071m

TY - JOUR

T1 - Chemical development of NBI-75043. Use of a flow reactor to circumvent a batch-limited metal#halogen exchange reaction

AU - Gross, Timothy D.

AU - Chou, Shine

AU - Bonneville, Daniel

AU - Gross, Raymond S.

AU - Wang, Peng

AU - Campopiano, Onorato

AU - Ouellette, Michael A.

AU - Zook, Scott E.

AU - Reddy, Jayachandra P.

AU - Moree, Wilna J.

AU - Jovic, Florence

AU - Chopade, Shubham

PY - 2008/9/19

Y1 - 2008/9/19

N2 - The discovery route and subsequent scale-up routes for NBI-75043 are presented. When traditional batch chemistry was found to limit the scale of a key reaction, a flow reactor was designed and optimized to provide an alternate method of production.

AB - The discovery route and subsequent scale-up routes for NBI-75043 are presented. When traditional batch chemistry was found to limit the scale of a key reaction, a flow reactor was designed and optimized to provide an alternate method of production.

UR - https://www.scopus.com/pages/publications/58149123661

U2 - 10.1021/op800071m

DO - 10.1021/op800071m

M3 - Article

AN - SCOPUS:58149123661

SN - 1083-6160

VL - 12

SP - 929

EP - 939

JO - Organic Process Research and Development

JF - Organic Process Research and Development

IS - 5

ER -

Chemical development of NBI-75043. Use of a flow reactor to circumvent a batch-limited metal#halogen exchange reaction

Abstract

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