Chemical development of NBI-75043. Use of a flow reactor to circumvent a batch-limited metal#halogen exchange reaction

Timothy D. Gross, Shine Chou, Daniel Bonneville, Raymond S. Gross, Peng Wang, Onorato Campopiano, Michael A. Ouellette, Scott E. Zook, Jayachandra P. Reddy, Wilna J. Moree, Florence Jovic, Shubham Chopade

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The discovery route and subsequent scale-up routes for NBI-75043 are presented. When traditional batch chemistry was found to limit the scale of a key reaction, a flow reactor was designed and optimized to provide an alternate method of production.

Original languageEnglish
Pages (from-to)929-939
Number of pages11
JournalOrganic Process Research and Development
Volume12
Issue number5
DOIs
StatePublished - 19 Sep 2008
Externally publishedYes

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