Chemical constituents of the roots of Pottsia laxiflora

Li Hua Mu; Ju Qiang-Feng; Ping Liu; Yuan Hu; Hai Xia Zhao

doi:10.1007/s10600-013-0450-2

Chemical constituents of the roots of Pottsia laxiflora

Li Hua Mu, Ju Qiang-Feng, Ping Liu, Yuan Hu, Hai Xia Zhao

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Two new natural products, 3-carbonyl-4-androstene-17-carboxylic acid (1) and trans-4-hydroxy-2-nonenoic acid (4), along with ten known compounds, were isolated from the genus Pottsia (Apocynaceae). Their structures were established on the basis of spectroscopic analysis, especially by means of 1D, 2D NMR and HR-ESI-MS analyses. All the compounds were isolated from the genus Pottsia for the first time. (+)Catechin (6), (-)epicatechin (7), cinnamtannin B-1 (11), and aesculitannin B (12) showed neuroprotective effects against corticosterone- induced neuronal SH-SY5Y cells and DPPH free-radical scavenging activity with EC₅₀ of 16.2,12.7, 5.6, and 4.8 μM.

Original language	English
Pages (from-to)	1004-1007
Number of pages	4
Journal	Chemistry of Natural Compounds
Volume	48
Issue number	6
DOIs	https://doi.org/10.1007/s10600-013-0450-2
State	Published - Jan 2013
Externally published	Yes

Keywords

DPPH
Pottsia laxiflora
chemical constituents
neuroprotective effect
new natural products

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10.1007/s10600-013-0450-2

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title = "Chemical constituents of the roots of Pottsia laxiflora",

abstract = "Two new natural products, 3-carbonyl-4-androstene-17-carboxylic acid (1) and trans-4-hydroxy-2-nonenoic acid (4), along with ten known compounds, were isolated from the genus Pottsia (Apocynaceae). Their structures were established on the basis of spectroscopic analysis, especially by means of 1D, 2D NMR and HR-ESI-MS analyses. All the compounds were isolated from the genus Pottsia for the first time. (+)Catechin (6), (-)epicatechin (7), cinnamtannin B-1 (11), and aesculitannin B (12) showed neuroprotective effects against corticosterone- induced neuronal SH-SY5Y cells and DPPH free-radical scavenging activity with EC50 of 16.2,12.7, 5.6, and 4.8 μM.",

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author = "Mu, {Li Hua} and Ju Qiang-Feng and Ping Liu and Yuan Hu and Zhao, {Hai Xia}",

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doi = "10.1007/s10600-013-0450-2",

language = "English",

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TY - JOUR

T1 - Chemical constituents of the roots of Pottsia laxiflora

AU - Mu, Li Hua

AU - Qiang-Feng, Ju

AU - Liu, Ping

AU - Hu, Yuan

AU - Zhao, Hai Xia

PY - 2013/1

Y1 - 2013/1

N2 - Two new natural products, 3-carbonyl-4-androstene-17-carboxylic acid (1) and trans-4-hydroxy-2-nonenoic acid (4), along with ten known compounds, were isolated from the genus Pottsia (Apocynaceae). Their structures were established on the basis of spectroscopic analysis, especially by means of 1D, 2D NMR and HR-ESI-MS analyses. All the compounds were isolated from the genus Pottsia for the first time. (+)Catechin (6), (-)epicatechin (7), cinnamtannin B-1 (11), and aesculitannin B (12) showed neuroprotective effects against corticosterone- induced neuronal SH-SY5Y cells and DPPH free-radical scavenging activity with EC50 of 16.2,12.7, 5.6, and 4.8 μM.

AB - Two new natural products, 3-carbonyl-4-androstene-17-carboxylic acid (1) and trans-4-hydroxy-2-nonenoic acid (4), along with ten known compounds, were isolated from the genus Pottsia (Apocynaceae). Their structures were established on the basis of spectroscopic analysis, especially by means of 1D, 2D NMR and HR-ESI-MS analyses. All the compounds were isolated from the genus Pottsia for the first time. (+)Catechin (6), (-)epicatechin (7), cinnamtannin B-1 (11), and aesculitannin B (12) showed neuroprotective effects against corticosterone- induced neuronal SH-SY5Y cells and DPPH free-radical scavenging activity with EC50 of 16.2,12.7, 5.6, and 4.8 μM.

KW - DPPH

KW - Pottsia laxiflora

KW - chemical constituents

KW - neuroprotective effect

KW - new natural products

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JO - Chemistry of Natural Compounds

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IS - 6

ER -

Chemical constituents of the roots of Pottsia laxiflora

Abstract

Keywords

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