Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis

Seshamma Reddy, Thomas Andl, Alexander Bagasra, Min Min Lu, Douglas J. Epstein, Edward E. Morrisey, Sarah E. Millar

Research output: Contribution to journalArticlepeer-review

372 Scopus citations

Abstract

Mutations in WNT effector genes perturb hair follicle morphogenesis, suggesting key roles for WNT proteins in this process. We show that expression of Wnts 10b and 10a is upregulated in placodes at the onset of follicle morphogenesis and in postnatal hair follicles beginning a new cycle of hair growth. The expression of additional Wnt genes is observed in follicles at later stages of differentiation. Among these, we find that Wnt5a is expressed in the developing dermal condensate of wild type but not Sonic hedgehog (Shh)-null embryos, indicating that Wnt5a is a target of SHH in hair follicle morphogenesis. These results identify candidates for several key follicular signals and suggest that WNT and SHH signaling pathways interact to regulate hair follicle morphogenesis.

Original languageEnglish
Pages (from-to)69-82
Number of pages14
JournalMechanisms of Development
Volume107
Issue number1-2
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Anagen
  • Basal cell carcinoma
  • Catagen
  • Dermal condensate
  • Dermal papilla
  • Dermis
  • Epidermis
  • Gene expression
  • Hair follicle
  • Hair growth cycle
  • Hair shaft
  • Inner root sheath
  • Morphogenesis
  • Mouse
  • Outer root sheath
  • Placode
  • Signaling
  • Skin
  • Sonic hedgehog
  • Telogen
  • Wnt

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