Abstract
Common variable immunodeficiency is characterized by an impairment in antibody production of at least two immunoglobulin isotypes, and abnormalities of both B and T cells have also been described. In this study, a profound alteration of the T cell receptor repertoire was noted, especially in CD8+ T cells, in CVID patients when compared to a control group. However, the higher number of oligoclonally expanded populations seen in the patient group was not dependent on age, whereas in the control group an age-related accumulation of these populations was noted. Expansion of CD8+ CD28- T cells in these patients is strongly correlated with T cell receptor repertoire restriction. Furthermore, analysis of cytokine production showed a statistically significant increase in IFN-γ secretion in the patient group. Lastly, CD94 and perforin were expressed at increased frequencies on CD8+ T cells in the patient group when compared to the control group. We speculate that these findings support the concept that CD8+ T cells may play an important regulatory role in CVID. (C) 2000 Academic Press.
Original language | English |
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Pages (from-to) | 248-258 |
Number of pages | 11 |
Journal | Clinical Immunology |
Volume | 97 |
Issue number | 3 |
DOIs | |
State | Published - 2000 |
Keywords
- Clonal expansion
- Human
- Immunodeficiency disease
- Suppression
- T cell receptors