15 Scopus citations


Purpose: To assess the diagnostic value of magnetic resonance imaging (MRI)-based radiomics features using machine learning (ML) models in characterizing solid renal neoplasms, in comparison/combination with qualitative radiologic evaluation. Methods: Retrospective analysis of 125 patients (mean age 59 years, 67% males) with solid renal neoplasms that underwent MRI before surgery. Qualitative (signal and enhancement characteristics) and quantitative radiomics analyses (histogram and texture features) were performed on T2-weighted imaging (WI), T1-WI pre- and post-contrast, and DWI. Mann–Whitney U test and receiver-operating characteristic analysis were used in a training set (n = 88) to evaluate diagnostic performance of qualitative and radiomics features for differentiation of renal cell carcinomas (RCCs) from benign lesions, and characterization of RCC subtypes (clear cell RCC [ccRCC] and papillary RCC [pRCC]). Random forest ML models were developed for discrimination between tumor types on the training set, and validated on an independent set (n = 37). Results: We assessed 104 RCCs (51 ccRCC, 29 pRCC, and 24 other subtypes) and 21 benign lesions in 125 patients. Significant qualitative and quantitative radiomics features (area under the curve [AUC] between 0.62 and 0.90) were included for ML analysis. Models with best diagnostic performance on validation sets showed AUC of 0.73 (confidence interval [CI] 0.5–0.96) for differentiating RCC from benign lesions (using combination of qualitative and radiomics features); AUC of 0.77 (CI 0.62–0.92) for diagnosing ccRCC (using radiomics features), and AUC of 0.74 (CI 0.53–0.95) for diagnosing pRCC (using qualitative features). Conclusion: ML models incorporating MRI-based radiomics features and qualitative radiologic assessment can help characterize renal masses.

Original languageEnglish
Pages (from-to)2840-2850
Number of pages11
JournalAbdominal Radiology
Issue number9
StatePublished - 1 Sep 2020


  • Histogram
  • Magnetic resonance imaging
  • Radiomics
  • Renal cell carcinoma
  • Renal mass
  • Texture


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