@article{99e9f86789494146b4a46e375c1b7c1e,
title = "Characterization of Glomerular and Tubulointerstitial Proteomes in a Case of Nonsteroidal Anti-Inflammatory Drug–Attributed Acute Kidney Injury A Clinical Pathologic Molecular Correlation",
abstract = "The major goals of the Kidney Precision Medicine Project (KPMPP) are to establish a molecular atlas of the kidney in health and disease and improve our understanding of the molecular drivers of CKD and AKI. In this clinical-pathologic-molecular correlation, we describe the case of a 38-year-old woman without any history of CKD who underwent a research kidney biopsy in the setting of AKI suspected to be due to nonsteroidal anti-inflammatory use after cesarean section delivery. The participant{\textquoteright}s histopathology was consistent with mild acute tubular injury, without significant interstitial fibrosis or tubular atrophy. This diagnosis was supported by analysis of the glomerular and tubulointerstitial proteomes. The proteomic interrogation revealed a molecular landscape that demonstrated differences in kidney prostaglandin synthesis that may be in response to nonsteroidal antiinflammatory drugs and signs of intrarenal inflammation and fibrosis that were not evident by histopathology alone.",
author = "{the Kidney Precision Medicine Project} and Parikh, {Samir V.} and Sethu Madhavan and John Shapiro and Richard Knight and Rosenberg, {Avi Z.} and Parikh, {Chirag R.} and Brad Rovin and Steven Menez and Richard Knight and Lecker, {Stewart H.} and Isaac Stillman and Steve Bogen and Beck, {Laurence H.} and Sushrut Waikar and McMahon, {Gearoid M.} and Astrid Weins and Colona, {Mia R.} and Nir Hacohen and Hoover, {Paul J.} and Mark Aulisio and Bush, {William S.} and Crawford, {Dana C.} and John O{\textquoteright}Toole and Emilio Poggio and John Sedor and Leslie Cooperman and Stacey Jolly and Leal Herlitz and Jane Nguyen and Agustin Gonzalez-Vicente and Ellen Palmer and Dianna Sendrey and Carissa Vi-Novskis and Bjornstad, {Petter M.} and Paul Appelbaum and Bar-Asch, {Jonathan M.} and Bomback, {Andrew S.} and D{\textquoteright}Agati, {Vivette D.} and Krzysztof Kiryluk and Karla Mehl and Canetta, {Pietro A.} and Ning Shang and Olivia Balderes and Satoru Kudose and Shweta Bansal and Theodore Alexandrov and Helmut Rennke and Azeloglu, {Evren U.} and Ravi Iyengar and Jens Hansen",
note = "Publisher Copyright: Copyright {\textcopyright} 2022 by the American Society of Nephrology.",
year = "2023",
month = mar,
doi = "10.2215/CJN.09260822",
language = "English",
volume = "18",
pages = "402--410",
journal = "Clinical Journal of the American Society of Nephrology",
issn = "1555-9041",
publisher = "American Society of Nephrology",
number = "3",
}