@article{9cacb981c17e40bd87bdd1fcd95225c8,
title = "Characterization of galanin-like immunoreactivity in the rat brain: Effects of neonatal glutamate treatment",
abstract = "Concentrations of the neuropeptide, galanin, were measured using a newly characterized radioimmunoassay in brain regions of adult male rats treated neonatally with monosodium glutamate. Galanin-like immunoreactivity (galanin-IR) was significantly reduced 57% in the median eminence, 15% in the medial basal hypothalamus, and 27% in the septal region when compared to untreated littermates. Concentrations of galanin-IR were reduced 22% in the preoptic region and unchanged in the parietal cortex. These studies suggest that glutamate-sensitive, galanin-containing neurons in the arcuate nucleus project to regions of the basal forebrain of the rat in addition to the median eminence. The galanin projection from the arcuate nucleus to the median eminence suggests that this peptide plays a role in the regulation of anterior pituitary hormone secretion.",
keywords = "Arcuate nucleus, Galanin, Hypothalamus, Median eminence, Monosodium glutamate, Pituitary",
author = "Gabriel, {Steven M.} and MacGarvey, {Usha M.} and Koenig, {James I.} and Swartz, {Kenton J.} and Martin, {Joseph B.} and Beal, {M. Flint}",
note = "Funding Information: Many neuropeptides that regulate anterior pituitary hormone secretion are found within neurons of the arcuate nucleus which project to the ME \[3, 9\]. The 50% decrease in galanin-IR in the ME of glutamate-treated rats indicates that at least 50% of the galanin-containing nerve terminals in the ME originate in the arcuate nucleus. This is supported by immunohistochemical findings \[13, 15\]. Since the galanin concentrations were not fully diminished by neonatal glutamate treatment, the ME may receive projections from galanin-containing neurons outside the arcuate nucleus, such as the periventricular and dorsomedial nucleus \[13, 15, 16\]. Alternatively, some galanin-containing neurons in the arcuate nucleus may have survived the neonatal glutamate treatment as a result of variability of the lesion or resistance to glutamate toxicity. Variability has been shown previously in glutamate-induced arcuate nucleus lesions \[14\]T. he presence of galanin cell bodies and their terminals within the arcuate nucleus-ME complex suggests that galanin may directly play a role in regulating anterior pituitary function.",
year = "1988",
month = apr,
day = "22",
doi = "10.1016/0304-3940(88)90155-3",
language = "English",
volume = "87",
pages = "114--120",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1-2",
}