Characterization of a novel immunocytolytic factor secreted by pancreatic adenocarcinoma

Celia M. Divino, Luz P. Angel, Steven T. Brower, Shu Hsia Chen

Research output: Contribution to journalArticlepeer-review

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We observed a putative immunocytolytic factor secreted in the supernatant of several pancreatic adenocarcinoma cell lines that induces apoptosis in lymphocytes. A marked reduction in the viability of the target splenocytes was evident after co-incubation with the supernatants from various pancreatic adenocarcinoma cell lines (human, hamster, and murine). The immunocytolytic effect was not evident with the conditioned media of normal pancreatic duct epithelial cells or other nonpancreatic tumor cells. Biologic activity of the supernatants was determined to be heat sensitive and reside in a 30- to 50-kDa range. Immune and functional assays have excluded known immunosuppressive factors.

Original languageEnglish
Pages (from-to)489-495
Number of pages7
JournalOncology Research
Issue number11-12
StatePublished - 1999


  • Apoptosis
  • Immunocytolytic factor
  • Lymphocytes
  • Pancreatic cancer


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