Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

Keyphrases

• Mouse-adapted SARS-CoV-2 100%
• N501Y 100%
• Receptor Binding Domain 100%
• Binding Affinity 66%
• Human ACE2 66%
• K417N 66%
• Molecular Mechanism 33%
• Respiratory Infection 33%
• COVID-19 33%
• SARS-CoV-2 Strains 33%
• Infectivity 33%
• ACE2 Receptor 33%
• Age-related 33%
• Pathogenicity 33%
• Receptor Binding 33%
• Rapid Evolution 33%
• Angiotensin-converting Enzyme 2 (ACE2) 33%
• Amino Acid Substitution 33%
• Cryogenic Electron Microscopy 33%
• Deep Sequencing 33%
• Gender-related 33%
• Respiratory Mortality 33%
• Electron Microscopic Analysis 33%
• SARS-CoV-2 Pathogenesis 33%
• Endogenous Receptors 33%
• Triple mutation 33%
• Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) 33%
• Rapid Adaptation 33%

Biochemistry, Genetics and Molecular Biology

• SARS Coronavirus 100%
• Receptor Binding 100%
• Binding Domain 75%
• Binding Affinity 50%
• Animal Model 25%
• Electron Microscopy 25%
• Deep Sequencing 25%
• Amino Acid Substitution 25%
• Cryoelectron Microscopy 25%
• Molecular Mechanism 25%

Immunology and Microbiology

• Severe Acute Respiratory Syndrome Coronavirus 2 100%
• Receptor Binding 100%
• Binding Affinity 50%
• COVID-19 25%
• Electron Microscopy 25%
• Pathogenicity 25%
• Cryo-Electron Microscopy 25%
• Amino Acid Substitution 25%
• Infection 25%