Characteristics of a Novel Serum Vitamin‐B12‐Binding Protein Associated with Hepatocellular Carcinoma

Samuel Waxman; Harriet S. Gilbert

doi:10.1111/j.1365-2141.1974.tb06789.x

Characteristics of a Novel Serum Vitamin‐B₁₂‐Binding Protein Associated with Hepatocellular Carcinoma

Samuel Waxman, Harriet S. Gilbert

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Summary. A novel protein designated as hepatoma B₁₂ binder (HBB), the predominant vitamin‐B12‐binding protein in the serum of two adolescents with hepatocellular carcinoma, has been characterized. HBB is more acidic and has different electrophoretic mobility and elution behaviour on gel filtration than normal or chronic myeloid leukaemia transcobalamin I. HBB is a member of the family of‘R’type vitamin‐B12‐binding proteins since it immunologically cross reacts with anti‐R antibody and does not deliver vitamin B₁₂ to the cell. HBB is unique in that it is tumour‐related, elaborated in enormous quantity and possesses physical characteristics best explained by a different carbohydrate composition from that of transcobalamin I.

Original language	English
Pages (from-to)	229-239
Number of pages	11
Journal	British Journal of Haematology
Volume	27
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2141.1974.tb06789.x
State	Published - Jun 1974
Externally published	Yes

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title = "Characteristics of a Novel Serum Vitamin‐B12‐Binding Protein Associated with Hepatocellular Carcinoma",

abstract = "Summary. A novel protein designated as hepatoma B12 binder (HBB), the predominant vitamin‐B12‐binding protein in the serum of two adolescents with hepatocellular carcinoma, has been characterized. HBB is more acidic and has different electrophoretic mobility and elution behaviour on gel filtration than normal or chronic myeloid leukaemia transcobalamin I. HBB is a member of the family of{\textquoteleft}R{\textquoteright}type vitamin‐B12‐binding proteins since it immunologically cross reacts with anti‐R antibody and does not deliver vitamin B12 to the cell. HBB is unique in that it is tumour‐related, elaborated in enormous quantity and possesses physical characteristics best explained by a different carbohydrate composition from that of transcobalamin I.",

author = "Samuel Waxman and Gilbert, \{Harriet S.\}",

year = "1974",

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doi = "10.1111/j.1365-2141.1974.tb06789.x",

language = "English",

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T1 - Characteristics of a Novel Serum Vitamin‐B12‐Binding Protein Associated with Hepatocellular Carcinoma

AU - Waxman, Samuel

AU - Gilbert, Harriet S.

PY - 1974/6

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N2 - Summary. A novel protein designated as hepatoma B12 binder (HBB), the predominant vitamin‐B12‐binding protein in the serum of two adolescents with hepatocellular carcinoma, has been characterized. HBB is more acidic and has different electrophoretic mobility and elution behaviour on gel filtration than normal or chronic myeloid leukaemia transcobalamin I. HBB is a member of the family of‘R’type vitamin‐B12‐binding proteins since it immunologically cross reacts with anti‐R antibody and does not deliver vitamin B12 to the cell. HBB is unique in that it is tumour‐related, elaborated in enormous quantity and possesses physical characteristics best explained by a different carbohydrate composition from that of transcobalamin I.

AB - Summary. A novel protein designated as hepatoma B12 binder (HBB), the predominant vitamin‐B12‐binding protein in the serum of two adolescents with hepatocellular carcinoma, has been characterized. HBB is more acidic and has different electrophoretic mobility and elution behaviour on gel filtration than normal or chronic myeloid leukaemia transcobalamin I. HBB is a member of the family of‘R’type vitamin‐B12‐binding proteins since it immunologically cross reacts with anti‐R antibody and does not deliver vitamin B12 to the cell. HBB is unique in that it is tumour‐related, elaborated in enormous quantity and possesses physical characteristics best explained by a different carbohydrate composition from that of transcobalamin I.

UR - https://www.scopus.com/pages/publications/0016075677

U2 - 10.1111/j.1365-2141.1974.tb06789.x

DO - 10.1111/j.1365-2141.1974.tb06789.x

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AN - SCOPUS:0016075677

SN - 0007-1048

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EP - 239

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 2

ER -

Characteristics of a Novel Serum Vitamin‐B12‐Binding Protein Associated with Hepatocellular Carcinoma

Abstract

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Characteristics of a Novel Serum Vitamin‐B₁₂‐Binding Protein Associated with Hepatocellular Carcinoma