Characteristics of a Novel Serum Vitamin‐B12‐Binding Protein Associated with Hepatocellular Carcinoma

Samuel Waxman, Harriet S. Gilbert

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Summary. A novel protein designated as hepatoma B12 binder (HBB), the predominant vitamin‐B12‐binding protein in the serum of two adolescents with hepatocellular carcinoma, has been characterized. HBB is more acidic and has different electrophoretic mobility and elution behaviour on gel filtration than normal or chronic myeloid leukaemia transcobalamin I. HBB is a member of the family of‘R’type vitamin‐B12‐binding proteins since it immunologically cross reacts with anti‐R antibody and does not deliver vitamin B12 to the cell. HBB is unique in that it is tumour‐related, elaborated in enormous quantity and possesses physical characteristics best explained by a different carbohydrate composition from that of transcobalamin I.

Original languageEnglish
Pages (from-to)229-239
Number of pages11
JournalBritish Journal of Haematology
Volume27
Issue number2
DOIs
StatePublished - Jun 1974
Externally publishedYes

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