Characteristics of a clone of endothelial cells derived from a line of normal adult rat lung cells

M. S. Parshley, J. M. Cerreta, I. Mandl, J. A. Fierer, G. M. Turino

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A strain of endothelial cells derived from a single cell cloned from a line of normal adult rat lung parenchyma has been maintained in tissue culture for more than 3 years. These cells have been identified as endothelial cells based on the combination of their growth characteristics, cell morphology as observed with both light and electron microscopy, and their physiological properties. They have continued to produce granules, which stain specifically for glycosaminoglycans with Alcian blue, for over 2 1/2 years. During the same period of time, glycosaminoglycans were identified biochemically in both cells and medium. They have maintained the ability to degrade bradykinin over this period as well.

Original languageEnglish
Pages (from-to)709-722
Number of pages14
JournalIn Vitro
Volume15
Issue number9
DOIs
StatePublished - Sep 1979
Externally publishedYes

Keywords

  • endothelial clone
  • normal adult rat lung

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