Characteristics and Treatment Patterns of Long-surviving Patients With Multiple Myeloma: Over 13 Years of Follow-up in the Connect MM Registry

Howard R. Terebelo, James Omel, Lynne I. Wagner, James W. Hardin, Robert M. Rifkin, Sikander Ailawadhi, Brian G.M. Durie, Mohit Narang, Kathleen Toomey, Cristina J. Gasparetto, Prashant Joshi, Edward Yu, E. Dawn Flick, Ying Ming Jou, Hans C. Lee, Rafat Abonour, Sundar Jagannath

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Over the last 15 years, improvements in patient management and treatments have been associated with longer survival in patients with multiple myeloma (MM). The Connect MM Registry is a long-running, US, multicenter, prospective observational cohort study of patients with newly diagnosed MM (NDMM). We assessed the demographics, clinical characteristics, and treatment patterns of long-term survivors (LTS) enrolled in this registry. Methods: Adults with NDMM (n = 3,011) were enrolled from 250 community, academic, and government sites across the US from 2009-2016. Baseline characteristics, treatment patterns, quality of life (QoL), and overall survival (OS) were examined among LTS, defined as patients with follow-up of ≥ 8 years after enrollment. Results: As of February 7, 2023, 518 patients were LTS and 2,493 were non-LTS. LTS were generally younger and had better performance status at enrollment compared with non-LTS. Most (65%) LTS received stem cell transplants and few (2%) experienced disease progression within 6 months of starting first line of therapy. At data cutoff, 63% of LTS were still on treatment at their most recent visit. QoL scores and QoL questionnaire completion rates were consistently higher among LTS than non-LTS. The estimated 8-year OS rate of all patients enrolled in the registry was 40%, comparable to an observed 8-year survival of 39% from the Surveillance, Epidemiology, and End Results (SEER) database. Conclusion: This analysis provides insights on long-surviving patients with MM using real-world data and therefore presents generalizability beyond data obtained in long-term follow-up of clinical trials, underscoring the need for longitudinal follow-up through registries.

Original languageEnglish
Pages (from-to)58-66
Number of pages9
JournalClinical Lymphoma, Myeloma and Leukemia
Volume25
Issue number1
DOIs
StatePublished - Jan 2025

Keywords

  • Newly diagnosed multiple myeloma
  • Registry
  • Stem cell transplant
  • Survival
  • Triplet therapy

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