Chapter 4.3 Microdialysis in the study of behavior reinforcement and inhibition

Pedro V. Rada, Ximena Páez, Luis F. Hernández, Nicole M. Avena, Bartley G. Hoebel

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Scopus citations


Brain microdialysis has been a valuable technique in the neuroscience field for more than 20 years. In vivo microdialysis in freely-moving rats allows measurement of neurotransmitter release in response to ongoing behaviors. In this chapter we review findings using microdialysis in the study of behavior reinforcement and inhibition. This literature leads to the development of the dopamine hypothesis of reward and the cholinergic hypothesis of aversion and their underlying neural circuitry. Within the context of natural rewards, we discuss many of the key findings using microdialysis in the nucleus accumbens, ventral tegmental area and hypothalamus to study feeding, water intake, and mating. Artificial rewards, such as intracranial self-stimulation and drug reward, are also reviewed. Finally, data are summarized that suggest a natural reward, sugar, may take on behavioral and neurochemical properties of an artificial reward, such as a drug of abuse, under certain conditions.

Original languageEnglish
Title of host publicationHandbook of Microdialysis Methods, Applications and Perspectives
EditorsBen Westerink, Thomas Cremers
Number of pages25
StatePublished - 2006
Externally publishedYes

Publication series

NameHandbook of Behavioral Neuroscience
ISSN (Print)1569-7339


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