17 Scopus citations


Hepatic fibrosis is a programmed response to parenchymal injury orchestrated primarily by the hepatic stellate cell (HSC), a pleiotropic non-parenchymal cell that resides in the perisinusoidal space of Disse. When the liver is injured, several signaling pathways converge upon the stellate cell, which promote transdifferentiation to an activated myofibroblast, and acquisition of phenotypic changes that culminate in extracellular matrix deposition. If the injury persists, hepatic fibrosis develops and may progress to cirrhosis, liver failure, hepatocellular cancer, and death. With HSCs positioned at the nexus of hepatic fibrosis, a greater appreciation of its complex biology may hasten our progress toward developing effective anti-fibrotic therapies.

Original languageEnglish
Title of host publicationStellate Cells in Health and Disease
PublisherElsevier Inc.
Number of pages22
ISBN (Electronic)9780128005446
ISBN (Print)9780128001349
StatePublished - 8 Apr 2015


  • Cirrhosis
  • Hepatic fibrosis
  • Hepatic stellate cell
  • Myofibroblast


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