TY - JOUR
T1 - Changes of 17-hydroxycorticosteroids and growth hormone during self-stimulation in monkeys
AU - Natelson, Benjamin H.
AU - Smith, Gerard P.
AU - Stokes, Peter E.
AU - Root, Allen W.
N1 - Funding Information:
1This work supported by National Institutes of Health Grants NS 08402, MH 12464, and HD 04840-01A1. B. H. N. was supported by NS 05114 and G. P. S. is a Career Development Awardee (K04 NS 38601). 2 Please send requests for reprints to: Benjamin H. Natelson, M. D., Department of Experimental Psychology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C. 20012. 3 The authors acknowledge the technical assistance of A. J. Strohmayer, R. Henry, D. Russ, M. Riccardo and Mrs. P. Ewerts. We are grateful to Dr. P. R. McHugh for his critical review of the manuscript. 4in conducting the research described in this report, the "Guide for Laboratory Animal Facilities and Care," as promulgated by the Committee on the Revision for Laboratory Animal Facilities and Care of the Institute of Laboratory Resources, National Academy of Sciences National Research Council, was followed.
PY - 1974/1
Y1 - 1974/1
N2 - To investigate the relationship of neuroendocrine responses to self-stimulation, we measured plasma 17-hydroxycorticosteroids (17-OHCS) and growth hormone (GH) during varying rates of self-stimulation of lateral hypothalamic sites in rhesus monkeys. Mean plasma 17-OHCS and GH were significantly higher during self-stimulation than during control. Since 17-OHCS and GH did not change significantly during extinction of self-stimulation, the increases of 17-OHCS and GH observed during self-stimulation were related to the neural consequences of self-stimulation and were not related to other conditions of these experiments. Increases of 17-OHCS tended to vary inversely with rates of self-stimulation. During relatively low rates (<1637 lever presses/hr), 17-OHCS increased (control = 40.3 ± 6.7 μg/100 ml; self-stimulation = 53.6 ± 5.2, p<0.01). During relatively higher rates (>1637 lever presses/hr), 17-OHCS did not change (control = 33.6 ± 3.9 μg/100 ml; self-stimulation = 35.7 ± 3.9). In contrast to plasma 17-OHCS, GH increased during relatively high rates of self-stimulation (control = 5.4 ± 1.0 ng/ml, self-stimulation = 9.4 ± 0.9, p<0.05), but not during relatively low rates (control = 5.2 ± 0.7 ng/ml, self-stimulation = 5.9 ± 1.0). The inverse relationship between change of 17-OHCS and rate of self-stimulation does not support the hypothesis that increases of plasma 17-OHCS during self-stimulation facilitate the performance or reinforcement of self-stimulation.
AB - To investigate the relationship of neuroendocrine responses to self-stimulation, we measured plasma 17-hydroxycorticosteroids (17-OHCS) and growth hormone (GH) during varying rates of self-stimulation of lateral hypothalamic sites in rhesus monkeys. Mean plasma 17-OHCS and GH were significantly higher during self-stimulation than during control. Since 17-OHCS and GH did not change significantly during extinction of self-stimulation, the increases of 17-OHCS and GH observed during self-stimulation were related to the neural consequences of self-stimulation and were not related to other conditions of these experiments. Increases of 17-OHCS tended to vary inversely with rates of self-stimulation. During relatively low rates (<1637 lever presses/hr), 17-OHCS increased (control = 40.3 ± 6.7 μg/100 ml; self-stimulation = 53.6 ± 5.2, p<0.01). During relatively higher rates (>1637 lever presses/hr), 17-OHCS did not change (control = 33.6 ± 3.9 μg/100 ml; self-stimulation = 35.7 ± 3.9). In contrast to plasma 17-OHCS, GH increased during relatively high rates of self-stimulation (control = 5.4 ± 1.0 ng/ml, self-stimulation = 9.4 ± 0.9, p<0.05), but not during relatively low rates (control = 5.2 ± 0.7 ng/ml, self-stimulation = 5.9 ± 1.0). The inverse relationship between change of 17-OHCS and rate of self-stimulation does not support the hypothesis that increases of plasma 17-OHCS during self-stimulation facilitate the performance or reinforcement of self-stimulation.
KW - Macaca mulatta
KW - Monkeys
KW - Plasma 17-hydroxycorticosteroids
KW - Plasma growth hormone
KW - Reinforcement
KW - Self-stimulation
UR - http://www.scopus.com/inward/record.url?scp=0015991201&partnerID=8YFLogxK
U2 - 10.1016/0031-9384(74)90075-4
DO - 10.1016/0031-9384(74)90075-4
M3 - Article
C2 - 4203991
AN - SCOPUS:0015991201
SN - 0031-9384
VL - 12
SP - 121
EP - 126
JO - Physiology and Behavior
JF - Physiology and Behavior
IS - 1
ER -