Abstract
Chemical dissolution of gallstones by feeding of chenodiol or ursodiol can be monitored by measuring the composition of bile acids in bile or serum. Changes in the composition of bile acids in bile already have been reported. We have measured the composition of bile acids in serum. Nineteen serum samples from 11 patients, 7 treated with chenodiol and 4 with ursodiol, were analyzed. The analyses included column liquid chromatography, solvent extraction, thin-layer chromatography, and gas liquid chromatography. The mean recovery of hyodeoxycholic acid standard was 73%. Treatment with chenodiol doubled the concentration of this bile acid (p<.02) and significantly increased ursodeoxycholic acid (p<.50). Treatment with ursodiol increased this bile acid several fold (p<.50). Both chenodiol and ursodiol treatment increased the total concentration of bile acids in serum. Studies of biliary bile acids showed that chenodiol treatment doubles its percentage composition and increases ursodiol, and ursodiol treatment increases ursodiol to up to 50% of total bile acid composition. Changes in the serum concentration of chenodiol and ursodiol can be used as indices of compliance.
| Original language | English |
|---|---|
| Pages (from-to) | 240-244 |
| Number of pages | 5 |
| Journal | Mount Sinai Journal of Medicine |
| Volume | 50 |
| Issue number | 3 |
| State | Published - 1983 |