Changes in plasma arginine vasopressin during transition from fetus to newborn following minimal trauma delivery of lambs and goats

C. W. Leffler, J. Crofton, D. P. Brooks, L. Share, J. R. Hessler, R. S. Green

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Vasopressin in umbilical arterial and venous blood is high at delivery and may be important in the maintenance of arterial pressure and absorption of lung liquid. We used chronically instrumented near-term fetal lambs and goats to investigate the changes in plasma vasopressin that occur during perinatal cardiovascular transition following cesarean section without labor. Plasma arginine vaospressin was more than 5 times greater 15 min following birth than immediately prior to clamping the umbilicus, and it fell progressively over the ensuing 2-5 h to levels not significantly different from before birth. Fifteen min after delivery, neither arterial pressure, blood gases, nor pH appeared to account for the increase.

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalBiology of the Neonate
Volume48
Issue number1
DOIs
StatePublished - 1985

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