Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys

Qian Li, Katarzyna Bozek, Chuan Xu, Yanan Guo, Jing Sun, Svante Pääbo, Chet C. Sherwood, Patrick R. Hof, John J. Ely, Yan Li, Lothar Willmitzer, Patrick Giavalisco, Philipp Khaitovich

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Lipids are essential components of the brain. Here, we conducted a comprehensive mass spectrometry-based analysis of lipidome composition in the prefrontal cortex of 40 humans, 40 chimpanzees, and 40 rhesus monkeys over postnatal development and adulthood. Of the 11,772 quantified lipid peaks, 7,589 change significantly along the lifespan. More than 60% of these changes occur prior to adulthood, with less than a quarter associated with myelination progression. Evolutionarily, 36% of the age-dependent lipids exhibit concentration profiles distinct to one of the three species; 488 (18%) of them were unique to humans. In both humans and chimpanzees, the greatest extent of species-specific differences occurs in early development. Human-specific lipidome differences, however, persist over most of the lifespan and reach their peak from 20 to 35 years of age, when compared with chimpanzee-specific ones.

Original languageEnglish
Pages (from-to)1155-1166
Number of pages12
JournalMolecular Biology and Evolution
Volume34
Issue number5
DOIs
StatePublished - 1 May 2017

Keywords

  • Brain
  • Development
  • Evolution
  • Lipidome

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