Changes in hippocampal CA1 population spikes following administration of delta-9-THC

Donald J. Weisz, Diana L. Gunnell, Timothy J. Teyler, Richard M. Vardaris

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16 Scopus citations


The effects of delta-9-tetrahy-drocannabinol (delta-9-THC) on monosynaptic population responses in hippocampal CA1 pyramidal cells were examined in acute rats for several doses and at several post injection time periods. Delta-9-THC enhanced paired pulse inhibition in a dose-dependent manner; however biphasic dose effects were observed on cell responses during low frequency potentiation and on population spikes elicited by a conditioning stimulus. The biphasic responses were such that 2-4 mg/kg THC (IP) excited while 16 mg/kg depressed the stimulus elicited CA1 response. For low doses of THC slight biphasic time effects were observed. Evidence presented suggests that some of THC's actions on hippocampus may be due to direct or indirect actions on GABA-mediated activity.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalBrain Research Bulletin
Issue number2
StatePublished - Feb 1982


  • Delta-9-tetrahydrocannabinol
  • GABA
  • Hippocampus
  • Low frequency potentiation
  • Paired pulse inhibition


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