Changes in Body Mass Index with Longer-Term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE)

Emma M. Kileel; Carlos D. Malvestutto; Janet Lo; Kathleen V. Fitch; Carl J. Fichtenbaum; Judith A. Aberg; Markella V. Zanni; Esteban Martinez; Nwora Lance Okeke; Princy Kumar; Esau Joao; Sara H. Bares; Daniel Berrner; Marek Smieja; Jhoanna C. Roa; Sara McCallum; Pamela S. Douglas; Heather J. Ribaudo; Steven K. Grinspoon

doi:10.1093/cid/ciad107

Changes in Body Mass Index with Longer-Term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE)

Emma M. Kileel
, Carlos D. Malvestutto
, Janet Lo
, Kathleen V. Fitch
, Carl J. Fichtenbaum
, Judith A. Aberg
, Markella V. Zanni
, Esteban Martinez
, Nwora Lance Okeke
, Princy Kumar
, Esau Joao
, Sara H. Bares
, Daniel Berrner
, Marek Smieja
, Jhoanna C. Roa
, Sara McCallum
, Pamela S. Douglas
, Heather J. Ribaudo
, Steven K. Grinspoon

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Over 2-years of follow-up, integrase strand transfer inhibitor (INSTI)-use was associated with weight gain among those on an INSTI <2 years at entry (+0.27 kg/m2/year; 95% confidence interval [CI],. 22 to. 33 vs +0.17 kg/m2/year; 95% CI,. 12 to. 23; P =. 01), but not those on an entry INSTI >2 years.

Original language	English
Pages (from-to)	2010-2013
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	76
Issue number	11
DOIs	https://doi.org/10.1093/cid/ciad107
State	Published - 1 Jun 2023

Keywords

HIV
body mass index (BMI)
integrase strand transfer inhibitors (INSTIs)
weight

Access to Document

10.1093/cid/ciad107

Cite this

Kileel, E. M., Malvestutto, C. D., Lo, J., Fitch, K. V., Fichtenbaum, C. J., Aberg, J. A., Zanni, M. V., Martinez, E., Okeke, N. L., Kumar, P., Joao, E., Bares, S. H., Berrner, D., Smieja, M., Roa, J. C., McCallum, S., Douglas, P. S., Ribaudo, H. J., & Grinspoon, S. K. (2023). Changes in Body Mass Index with Longer-Term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE). Clinical Infectious Diseases, 76(11), 2010-2013. https://doi.org/10.1093/cid/ciad107

@article{fa90db8b46f841c581f710a5bb1620e9,

title = "Changes in Body Mass Index with Longer-Term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE)",

abstract = "Over 2-years of follow-up, integrase strand transfer inhibitor (INSTI)-use was associated with weight gain among those on an INSTI <2 years at entry (+0.27 kg/m2/year; 95\% confidence interval [CI],. 22 to. 33 vs +0.17 kg/m2/year; 95\% CI,. 12 to. 23; P =. 01), but not those on an entry INSTI >2 years.",

keywords = "HIV, body mass index (BMI), integrase strand transfer inhibitors (INSTIs), weight",

author = "Kileel, \{Emma M.\} and Malvestutto, \{Carlos D.\} and Janet Lo and Fitch, \{Kathleen V.\} and Fichtenbaum, \{Carl J.\} and Aberg, \{Judith A.\} and Zanni, \{Markella V.\} and Esteban Martinez and Okeke, \{Nwora Lance\} and Princy Kumar and Esau Joao and Bares, \{Sara H.\} and Daniel Berrner and Marek Smieja and Roa, \{Jhoanna C.\} and Sara McCallum and Douglas, \{Pamela S.\} and Ribaudo, \{Heather J.\} and Grinspoon, \{Steven K.\}",

year = "2023",

month = jun,

day = "1",

doi = "10.1093/cid/ciad107",

language = "English",

volume = "76",

pages = "2010--2013",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "11",

}

Kileel, EM, Malvestutto, CD, Lo, J, Fitch, KV, Fichtenbaum, CJ, Aberg, JA, Zanni, MV, Martinez, E, Okeke, NL, Kumar, P, Joao, E, Bares, SH, Berrner, D, Smieja, M, Roa, JC, McCallum, S, Douglas, PS, Ribaudo, HJ & Grinspoon, SK 2023, 'Changes in Body Mass Index with Longer-Term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE)', Clinical Infectious Diseases, vol. 76, no. 11, pp. 2010-2013. https://doi.org/10.1093/cid/ciad107

Changes in Body Mass Index with Longer-Term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE). / Kileel, Emma M.; Malvestutto, Carlos D.; Lo, Janet et al.
In: Clinical Infectious Diseases, Vol. 76, No. 11, 01.06.2023, p. 2010-2013.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Changes in Body Mass Index with Longer-Term Integrase Inhibitor Use

T2 - A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE)

AU - Kileel, Emma M.

AU - Malvestutto, Carlos D.

AU - Lo, Janet

AU - Fitch, Kathleen V.

AU - Fichtenbaum, Carl J.

AU - Aberg, Judith A.

AU - Zanni, Markella V.

AU - Martinez, Esteban

AU - Okeke, Nwora Lance

AU - Kumar, Princy

AU - Joao, Esau

AU - Bares, Sara H.

AU - Berrner, Daniel

AU - Smieja, Marek

AU - Roa, Jhoanna C.

AU - McCallum, Sara

AU - Douglas, Pamela S.

AU - Ribaudo, Heather J.

AU - Grinspoon, Steven K.

PY - 2023/6/1

Y1 - 2023/6/1

N2 - Over 2-years of follow-up, integrase strand transfer inhibitor (INSTI)-use was associated with weight gain among those on an INSTI <2 years at entry (+0.27 kg/m2/year; 95% confidence interval [CI],. 22 to. 33 vs +0.17 kg/m2/year; 95% CI,. 12 to. 23; P =. 01), but not those on an entry INSTI >2 years.

AB - Over 2-years of follow-up, integrase strand transfer inhibitor (INSTI)-use was associated with weight gain among those on an INSTI <2 years at entry (+0.27 kg/m2/year; 95% confidence interval [CI],. 22 to. 33 vs +0.17 kg/m2/year; 95% CI,. 12 to. 23; P =. 01), but not those on an entry INSTI >2 years.

KW - HIV

KW - body mass index (BMI)

KW - integrase strand transfer inhibitors (INSTIs)

KW - weight

UR - https://www.scopus.com/pages/publications/85162195340

U2 - 10.1093/cid/ciad107

DO - 10.1093/cid/ciad107

M3 - Article

C2 - 36825498

AN - SCOPUS:85162195340

SN - 1058-4838

VL - 76

SP - 2010

EP - 2013

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 11

ER -

Changes in Body Mass Index with Longer-Term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE)

Abstract

Keywords

Access to Document

Fingerprint

Cite this