Changes in Body Mass Index with Longer-Term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE)

Emma M. Kileel; Carlos D. Malvestutto; Janet Lo; Kathleen V. Fitch; Carl J. Fichtenbaum; Judith A. Aberg; Markella V. Zanni; Esteban Martinez; Nwora Lance Okeke; Princy Kumar; Esau Joao; Sara H. Bares; Daniel Berrner; Marek Smieja; Jhoanna C. Roa; Sara McCallum; Pamela S. Douglas; Heather J. Ribaudo; Steven K. Grinspoon

doi:10.1093/cid/ciad107

Changes in Body Mass Index with Longer-Term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE)

Emma M. Kileel
, Carlos D. Malvestutto
, Janet Lo
, Kathleen V. Fitch
, Carl J. Fichtenbaum
, Judith A. Aberg
, Markella V. Zanni
, Esteban Martinez
, Nwora Lance Okeke
, Princy Kumar
, Esau Joao
, Sara H. Bares
, Daniel Berrner
, Marek Smieja
, Jhoanna C. Roa
, Sara McCallum
, Pamela S. Douglas
, Heather J. Ribaudo
, Steven K. Grinspoon

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Over 2-years of follow-up, integrase strand transfer inhibitor (INSTI)-use was associated with weight gain among those on an INSTI <2 years at entry (+0.27 kg/m2/year; 95% confidence interval [CI],. 22 to. 33 vs +0.17 kg/m2/year; 95% CI,. 12 to. 23; P =. 01), but not those on an entry INSTI >2 years.

Original language	English
Pages (from-to)	2010-2013
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	76
Issue number	11
DOIs	https://doi.org/10.1093/cid/ciad107
State	Published - 1 Jun 2023

Keywords

HIV
body mass index (BMI)
integrase strand transfer inhibitors (INSTIs)
weight

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10.1093/cid/ciad107

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Kileel, E. M., Malvestutto, C. D., Lo, J., Fitch, K. V., Fichtenbaum, C. J., Aberg, J. A., Zanni, M. V., Martinez, E., Okeke, N. L., Kumar, P., Joao, E., Bares, S. H., Berrner, D., Smieja, M., Roa, J. C., McCallum, S., Douglas, P. S., Ribaudo, H. J., & Grinspoon, S. K. (2023). Changes in Body Mass Index with Longer-Term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE). Clinical Infectious Diseases, 76(11), 2010-2013. https://doi.org/10.1093/cid/ciad107

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title = "Changes in Body Mass Index with Longer-Term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE)",

abstract = "Over 2-years of follow-up, integrase strand transfer inhibitor (INSTI)-use was associated with weight gain among those on an INSTI <2 years at entry (+0.27 kg/m2/year; 95\% confidence interval [CI],. 22 to. 33 vs +0.17 kg/m2/year; 95\% CI,. 12 to. 23; P =. 01), but not those on an entry INSTI >2 years.",

keywords = "HIV, body mass index (BMI), integrase strand transfer inhibitors (INSTIs), weight",

author = "Kileel, \{Emma M.\} and Malvestutto, \{Carlos D.\} and Janet Lo and Fitch, \{Kathleen V.\} and Fichtenbaum, \{Carl J.\} and Aberg, \{Judith A.\} and Zanni, \{Markella V.\} and Esteban Martinez and Okeke, \{Nwora Lance\} and Princy Kumar and Esau Joao and Bares, \{Sara H.\} and Daniel Berrner and Marek Smieja and Roa, \{Jhoanna C.\} and Sara McCallum and Douglas, \{Pamela S.\} and Ribaudo, \{Heather J.\} and Grinspoon, \{Steven K.\}",

year = "2023",

month = jun,

day = "1",

doi = "10.1093/cid/ciad107",

language = "English",

volume = "76",

pages = "2010--2013",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "11",

}

Kileel, EM, Malvestutto, CD, Lo, J, Fitch, KV, Fichtenbaum, CJ, Aberg, JA, Zanni, MV, Martinez, E, Okeke, NL, Kumar, P, Joao, E, Bares, SH, Berrner, D, Smieja, M, Roa, JC, McCallum, S, Douglas, PS, Ribaudo, HJ & Grinspoon, SK 2023, 'Changes in Body Mass Index with Longer-Term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE)', Clinical Infectious Diseases, vol. 76, no. 11, pp. 2010-2013. https://doi.org/10.1093/cid/ciad107

Changes in Body Mass Index with Longer-Term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE). / Kileel, Emma M.; Malvestutto, Carlos D.; Lo, Janet et al.
In: Clinical Infectious Diseases, Vol. 76, No. 11, 01.06.2023, p. 2010-2013.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Changes in Body Mass Index with Longer-Term Integrase Inhibitor Use

T2 - A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE)

AU - Kileel, Emma M.

AU - Malvestutto, Carlos D.

AU - Lo, Janet

AU - Fitch, Kathleen V.

AU - Fichtenbaum, Carl J.

AU - Aberg, Judith A.

AU - Zanni, Markella V.

AU - Martinez, Esteban

AU - Okeke, Nwora Lance

AU - Kumar, Princy

AU - Joao, Esau

AU - Bares, Sara H.

AU - Berrner, Daniel

AU - Smieja, Marek

AU - Roa, Jhoanna C.

AU - McCallum, Sara

AU - Douglas, Pamela S.

AU - Ribaudo, Heather J.

AU - Grinspoon, Steven K.

PY - 2023/6/1

Y1 - 2023/6/1

N2 - Over 2-years of follow-up, integrase strand transfer inhibitor (INSTI)-use was associated with weight gain among those on an INSTI <2 years at entry (+0.27 kg/m2/year; 95% confidence interval [CI],. 22 to. 33 vs +0.17 kg/m2/year; 95% CI,. 12 to. 23; P =. 01), but not those on an entry INSTI >2 years.

AB - Over 2-years of follow-up, integrase strand transfer inhibitor (INSTI)-use was associated with weight gain among those on an INSTI <2 years at entry (+0.27 kg/m2/year; 95% confidence interval [CI],. 22 to. 33 vs +0.17 kg/m2/year; 95% CI,. 12 to. 23; P =. 01), but not those on an entry INSTI >2 years.

KW - HIV

KW - body mass index (BMI)

KW - integrase strand transfer inhibitors (INSTIs)

KW - weight

UR - https://www.scopus.com/pages/publications/85162195340

U2 - 10.1093/cid/ciad107

DO - 10.1093/cid/ciad107

M3 - Article

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AN - SCOPUS:85162195340

SN - 1058-4838

VL - 76

SP - 2010

EP - 2013

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 11

ER -

Changes in Body Mass Index with Longer-Term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE)

Abstract

Keywords

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