Changes in angiotensin converting enzyme, electrocardiograms and histology during sedation and general anaesthesia in dogs

A. K. Sharma, Apra Shahi, Naveen Kumar, S. K. Maiti, Jagmohan, R. Singh

Research output: Contribution to journalArticlepeer-review

Abstract

In present study, 16 dogs were divided into 4 equal groups to study the status of angiotensin converting enzyme, electrocardiograms and histomorphology in sedated and anaesthetized dogs. All the dogs were premedicated with atropine sulphate (0.045 mg/kg). After 20 min, detomidine (0.2 mg/kg) in groups 1 and 3 and xylazine (2 mg/kg) in groups 2 and 4 were intramuscularly injected, followed by thiopental sodium after 15 min, intravenously, till-effect for anaesthetic induction in animals of groups 3 and 4. The angiotensin converting enzyme (ACE) activity was found significantly increased at 15-45 min in group 1 and at 30 min in group 2. Whereas, significant increase in ACE in animals of groups 3 and 4 was recorded at 5-15 min and 5 min, respectively. The significant hypertension persisted for 60 min in animals of groups 1 and 3, and for 30 min in animals of groups 2 and 4. In groups 1 and 2, sinoatrial block in all dogs and second degree AV block in 1 dog of each group were seen within 2-15 min of drug administration. Ventricular premature contractions at 15-30 min were recorded in 1 dog of group 2 and group 4. The plasma electrolytes were nonsignificantly altered. Microscopically, haemorrhages with engorgement of blood vessels was seen in the parenchymatous organs. In lungs, the haemorrhages along with mild edema were seen in the perivascular areas and alveoli. Both xylazine and detomidine with and without thiopental sodium had increased the ACE activity, which resulted in proportionate hypertension, alongwith changes in alveolar epithelium and pulmonary endothelium during peak effect.

Original languageEnglish
Pages (from-to)19-23
Number of pages5
JournalIndian Journal of Animal Sciences
Volume79
Issue number1
StatePublished - Jan 2009
Externally publishedYes

Keywords

  • Anaesthesia
  • Angiotensin converting enzyme
  • Arterial blood pressure
  • Dogs
  • Electrocardiogram

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