Abstract
The aim of this study was to compare the differences in the levels of a highly sensitive cardiac troponin T (Hs-cTnT) between Losartan (LOS) plus hydrochlorothiazide (HCTZ) and amlodipine. Seventy-eight hypertensive patients were randomized to receive LOS/HCTZ or amlodipine for 8 weeks. Both treatments decreased clinic and 24-hour blood pressure to the same extent. The Hs-cTnT level was significantly reduced in the amlodipine group (P < .05), but such a reduction was not found in the LOS/HCTZ group in the upper half group of Hs-cTnT level at baseline. Amlodipine had a more beneficial effect than LOS/HCTZ in patients with high Hs-cTnT levels.
| Original language | English |
|---|---|
| Pages (from-to) | 40-44 |
| Number of pages | 5 |
| Journal | Clinical and Experimental Hypertension |
| Volume | 35 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2013 |
| Externally published | Yes |
Keywords
- A highly sensitive assay for cardiac troponin T
- Angiotensin II type I receptor blocker
- Calcium channel blocker
- Hydrochlorothiazide
- Hypertension
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